PMID: 2119953Oct 1, 1990Paper

Antigen-presenting capacity in patients with sarcoidosis

Chest
Y InaA Miyachi

Abstract

Antigen-presenting capacity by monocytes and AMs was determined in 13 patients with sarcoidosis and nine healthy control subjects, using PPD as the antigen. The patients and healthy control subjects all had positive PPD skin tests. Monocytes from both the control subjects and the patients with sarcoidosis exhibited antigen-presenting capacity to autologous peripheral T-lymphocytes, without any significant difference between the two groups. The AMs from patients, but not control subjects, demonstrated antigen-presenting capacity to autologous peripheral T-lymphocytes. Antigen-presenting capacity by monocytes and AMs to lung T-lymphocytes was lower than to peripheral T-lymphocytes, but not significantly. Antigen-presenting capacity was not significantly different between patients with sarcoidosis who had positive and negative PPD skin tests. The mechanism of enhanced antigen-presenting capacity by AMs in sarcoidosis is uncertain at present, but no significant difference was observed in DR antigen expression on AMs between controls and patients with sarcoidosis, and the addition of exogenous IL-1 or IFN-gamma did not induce antigen-presenting capacity by AMs in controls, suggesting that neither increased DR antigen expression on A...Continue Reading

References

Jul 1, 1989·The American Review of Respiratory Disease·J R SpurzemR G Crystal
Apr 1, 1987·Radiology·J W GurneyS I Rennard
Jan 1, 1985·The Journal of Clinical Investigation·A VenetR G Crystal
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C Cowing, J M Chapdelaine
Aug 20, 1981·The New England Journal of Medicine·G W Hunninghake, R G Crystal
Apr 7, 1983·The New England Journal of Medicine·P PinkstonR G Crystal
Mar 13, 1980·The New England Journal of Medicine·G W HunninghakeR G Crystal

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Citations

Jan 1, 1994·Lung·J Hamacher, T Schaberg
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·P J FoleyR M du Bois
Sep 1, 1992·Chest·D L Smith, R D deShazo
Jan 2, 2015·Allergy, Asthma & Immunology Research·Soo Jung ChoChun Geun Lee
May 1, 1994·Clinical and Experimental Immunology·C E HavenithE C Hoefsmit

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