PMID: 6972042Mar 1, 1981Paper

Antigen-presenting cell function in induction of helper T cells for cytotoxic T-lymphocyte responses: evidence for antigen processing

Proceedings of the National Academy of Sciences of the United States of America
O WeinbergerS J Burakoff

Abstract

We demonstrate that splenic adherent cells (SACs) play an active role in the presentation of H-2Kk antigen for an alloreactive cytotoxic T-lymphocyte (CTL) response. If antigen is incubated with SACs for 12 hr, they will provide maximal stimulation and present the antigen in the context of their Ia molecules. UV irradiation of these SACs, prior to the 12-hr incubation with H-2Kk antigen, abrogates this stimulatory capacity. Macrophage-bound antigen is not sufficient for stimulation of a response; a second signal is required as well, that, in our system, is provided by phorbol myristic acetate. The SACs are involved in the activation of helper T cells; however, they are not required for presentation of antigen to the precytotoxic T-lymphocyte, which requires two signals for activation, one provided by antigen and the other by a T-cell-derived helper factor.

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M I GreeneB Benacerraf
Apr 1, 1970·The Journal of Experimental Medicine·E R Unanue, J C Cerottini
Feb 14, 1980·Nature·E L LarssonA Coutinho
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·N L LetvinR N Germain
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·O WeinbergerS J Burakoff
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J W Mier, R C Gallo

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Citations

Jan 1, 1982·Acta neurochirurgica·M K GatelyP L Kornblith
Aug 1, 1981·The Journal of Experimental Medicine·C S Reiss, S J Burakoff
Jun 20, 1998·Sexually Transmitted Infections·C Sonnex
Sep 1, 1986·Cellular Immunology·C Cognot, T Reme
Apr 17, 2008·Biochemical and Biophysical Research Communications·Arun T Pores-FernandoAdam Zweifach
Sep 13, 2005·Developmental and Comparative Immunology·Norihisa NishimichiHaruo Matsuda
Jan 1, 1983·Immunological Reviews·K L Rock, B Benacerraf
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·S H Herrmann, M F Mescher
May 4, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charles WiraGrant Yeaman
Jan 17, 1983·Klinische Wochenschrift·W SolbachH Wagner
Oct 1, 1984·European Journal of Immunology·R Di Pauli, T Brückner

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