PMID: 8948293Nov 1, 1996Paper

Antigen-presenting cells but not lymphocytes in the joint may indicate the cause of reactive arthritis

British Journal of Rheumatology
A J StaggS C Knight

Abstract

T cells and antigen-presenting cells (APC) accumulate in the joint in reactive arthritis and there are reports that the T cells are a population selected for responsiveness to the causative agent. In this work, the latter view is questioned by detailed studies of the antigen specificities of the lymphocytes within the joint (SFMC) and peripheral blood (PBMC) of patients with reactive arthritis triggered by infection with Chlamydia trachomatis. Using a hanging-drop microculture system. SFMC displayed enhanced responses not only to antigens from the triggering organism, but also to other antigens, including PPD and tetanus toxoid, to which the patients were likely to have had prior exposure. No evidence was obtained for a dominant cross-reactive T-cell response to epitopes common to these antigen preparations, confirming the polyclonal nature of the infiltrate. In contrast to the broad specificity of the T-cell infiltrate, two experimental approaches indicated that APC within the joint carried chlamydial antigen. The failure of antigen-bearing APC to interact with T cells at this site may underlie the inability to clear microbial antigen from the joint.

Citations

Jul 13, 2000·Veterinary Microbiology·K D Everett
Apr 16, 2004·Clinical Microbiology Reviews·Inés ColmegnaLuis R Espinoza
Feb 15, 2001·Annals of the Rheumatic Diseases·D Taylor-Robinson, A Keat
Jul 11, 2006·Postgraduate Medical Journal·S S HamdulayA Keat
Aug 29, 2000·Sexually Transmitted Infections·J S Gaston
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S J BellA J Stagg
Jul 17, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D Taylor-RobinsonM Rooney

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