Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1beta and interleukin-6

Endocrinology
P J SimonsH A Drexhage

Abstract

An accumulation of antigen-presenting dendritic cells (DC) in the thyroid gland, followed by thyroid autoimmune reactivity, occurs in normal Wistar rats during iodine deficiency, and spontaneously in diabetic-prone Biobreeding rats. This intrathyroidal DC accumulation coincides with an enhanced growth rate and metabolism of the thyrocytes, suggesting that both phenomena are related. Because DC are known to regulate the hormone synthesis and growth in other endocrine systems (i.e. the pituitary, the ovary, and the testis), we tested the hypothesis that DC, known for their superb accessory cell function in T cell stimulation, act as regulators of thyrocyte proliferation (and hormone secretion). We investigated the effect of (Nycodenz density gradient) purified splenic DC from Wistar rats on the growth rate of and thyroid hormone secretion by Wistar thyroid follicles (collagenase dispersion) in culture. Various numbers of DC and follicles were cocultured during 24 h. The proliferative capacity of thyrocytes was measured by adding tritiated thymidine (3H-TdR) and bromodeoxyuridine, the hormone secretion into the culture fluid was measured by using a conventional T3 RIA. Furthermore, antibodies directed against interleukin-1beta (IL...Continue Reading

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Citations

Nov 8, 2014·Journal of Neural Transmission·Charlotte PeterseinHubertus Himmerich
Jan 1, 2005·Indian Journal of Clinical Biochemistry : IJCB·Manorama SwainBinoy Kumar Mohanty
Dec 22, 2009·Expert Review of Neurotherapeutics·Roosmarijn C DrexhageHemmo A Drexhage
Mar 10, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·J G RosmalenF Homo-Delarche
Aug 24, 2018·Cell Communication and Signaling : CCS·Ichiro MurakamiFrancis Jaubert
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·J G RosmalenH A Drexhage

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