PMID: 8610982Feb 13, 1996Paper

Antigen-presenting function of the mouse CD1 molecule

Annals of the New York Academy of Sciences
S TangriM Kronenberg

Abstract

CD1 molecules are distantly related to major histocompatibility complex (MHC)-encoded class I molecules, and they are coexpressed with beta2 microglobulin (beta2m). In the mouse, CD1 is expressed by intestinal epithelial cells and also by some cells in spleen and lymph node. We have shown that surface expression of mouse CD1 (mCD1) is not dependent upon a functional transporter associated with antigen processing (TAP). This, and other data, suggest that mCD1 may acquire peptides in an intracellular compartment other than the endoplasmic reticulum, where classical class I molecules bind peptide. mCD1 molecules also are distinct from classical class I molecules with regard to the types of peptides that they bind. We have demonstrated that mCD1 molecules preferentially bind peptides much longer than the 8-9 amino acids typical of the peptides that bind to classical class I molecules. The sequence motif for mCD1 peptide binding is characterized by the presence of bulky and hydrophobic amino acid side chains. We have generated mCD1-restricted and peptide-specific T-cell lines, thereby demonstrating the immunologic relevance of peptide binding to mCD1. The reactive T cells are TCR alphabeta+ and CD8+, a phenotype typical of many lymp...Continue Reading

References

Mar 1, 1979·European Journal of Immunology·A J McMichaelC Milstein
Nov 2, 1990·Science·P A BleicherC Terhorst
Aug 2, 1990·Nature·H G LjunggrenK Kärre
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S P BalkC Terhorst
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E FithianR Edelson
Sep 1, 1994·Human Immunology·D HanauH de la Salle
Sep 1, 1993·The Journal of Experimental Medicine·A PanjaL Mayer
Aug 1, 1994·Trends in Cell Biology·I V Sandoval, O Bakke

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Citations

Jan 1, 1997·Biopolymers·M A Batalia, E J Collins
Aug 1, 1997·Current Opinion in Immunology·J K Maher, M Kronenberg
Oct 31, 1998·Current Opinion in Immunology·S Cobbold, H Waldmann
Feb 28, 2002·Annual Review of Immunology·Pierre GuermonprezSebastian Amigorena

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