Antigen processing and remodeling of the endosomal pathway: requirements for antigen cross-presentation.

Frontiers in Immunology
Ewoud Bernardus CompeerMarianne Boes

Abstract

Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cells capable of antigen cross-presentation, identification of mechanisms involved is still ongoing. Especially amongst dendritic cells (DC), there are specialized subsets that are highly proficient at antigen cross-presentation. We here present a focused survey on the cell biological processes in the endosomal pathway that support antigen cross-presentation. This review highlights DC-intrinsic mechanisms that facilitate the cross-presentation of endocytosed antigen, including receptor-mediated uptake, maturation-induced endosomal sorting of membrane proteins, dynamic remodeling of endosomal structures and cell surface-directed endosomal trafficking. We will conclude with the description of pathogen-induced deviation of endosomal processing, and discuss how immune evasion strategies pertaining endosomal trafficking may preclude antigen cross-presentation.

Citations

Jun 10, 2015·Journal of Immunological Methods·Kazem AshjaeiKarin Hoffmann-Sommergruber
Oct 20, 2015·Communicative & Integrative Biology·Ewoud B Compeer, Marianne Boes
Jul 29, 2015·Journal of Cellular and Molecular Medicine·Beate PoschChristine Heufler
Mar 30, 2013·Molecular & Cellular Proteomics : MCP·Elena MilnerArie Admon
Jan 23, 2019·Angewandte Chemie·Ved PrakashYamuna Krishnan
Jun 14, 2019·Frontiers in Immunology·Marios KoutsakosKatherine Kedzierska
Jan 30, 2021·Frontiers in Molecular Biosciences·Florian HoferKlaus R Liedl
Dec 24, 2017·Molecular Immunology·Ralph E Vatner, Edith M Janssen
Sep 3, 2019·Journal of Chemical Theory and Computation·Florian HoferKlaus R Liedl
Aug 14, 2020·ACS Nano·Mohammad Murshid AlamLaura L Kiessling

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Methods Mentioned

BETA
GTPase
ubiquitination
GTPases

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