PMID: 6165797Feb 1, 1981Paper

Antigen-reactive T cell clones. II. Unique homozygous and (high responder x low responder)F1 hybrid antigen-presenting determinants detected using poly(Tyr, Glu)-poly D, L-Ala--poly Lys-reactive T cell clones

The Journal of Experimental Medicine
M Kimoto, C G Fathman

Abstract

Using murine (T,G)-A--L-reactive T cell clones, we have demonstrated the existence of unique homozygous antigen-presenting determinants expressed on C57bl/6 mice, controlled by the I-A subregion of the murine major histocompatibility complex (MHC), which are not expressed on semisyngeneic (C57Bl/6 x A/J)F1 [(B6A)F1] cells. Additionally, we were able to demonstrate that there exist (T,G)-A--L-reactive clones in F1 mice derived between low responder and high responder parents [(B6A)F1] that recognize antigen in association with transcomplementing hybrid I-A subregion determinants expressed uniquely on (B6A)F1 cells not expressed on cells of either of the parental strains. These data suggest that phenotypic high responsiveness exhibited by (higher responder x low responder)F1 mice was not simply controlled by the high responder parental genome, but was controlled at the phenotypic level of expression of antigen-presenting determinants. Such antigen-presenting determinants can be created by complementation using products of the low responder as well as high responder genome. The significance of the existence of such F1 specific hybrid antigen-presenting determinants for T cell specificity and recognition of self was discussed.

References

Dec 1, 1979·The Journal of Experimental Medicine·I F McKenzieH I Kohn
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Sep 19, 1979·The Journal of Experimental Medicine·R M ZinkernagelG Callahan
Jun 1, 1972·The Journal of Experimental Medicine·H O McDevittG D Snell

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Citations

Jan 1, 1982·Journal of Immunological Methods·B Sredni
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y TseT H Hansen
May 1, 1985·Clinical Immunology and Immunopathology·A R Pachner, F S Kantor
Feb 1, 1982·Immunology Today·R H Schwartz
Sep 1, 1982·Immunology Today·W E Paul, C Bona
Jan 1, 1986·Microbiology and Immunology·M Kimoto, C G Fathman

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