PMID: 6982759Oct 1, 1982Paper

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

Cell
E L ReinherzS F Schlossman

Abstract

Four distinct surface molecules on human T cells are defined by the monoclonal antibodies anti-T1, anti-T3 (anti-T3A), anti-T11 and anti-T12. Following cell binding, anti-T3 (anti-T3A) and anti-T1 induce independent modulation of their respective ligands, whereas anti-T11 and anti-T12 do not. To explore the biological consequences of this modulation, we used cloned populations of T4 and T8 cytotoxic T lymphocytes. Anti-T3 (anti-T3A), but not anti-T1, inhibits cytotoxic T lymphocyte effector function by T4 and T8 clones as well as antigen-specific T cell recognition. The latter is not secondary to a generalized inhibitory effect since responsiveness to interleukin 2 is maintained. Moreover, after modulation, cytotoxic T lymphocytes recover cytolytic function in parallel with reexpression of surface T3 molecules. We provide evidence for a direct linkage between antigen recognition by T lymphocytes and surface expression of the T3 molecular complex.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
May 1, 1973·European Journal of Immunology·P M KnopfR Hyman
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T W ChangG Goldstein
Oct 30, 1981·Science·I H Pastan, M C Willingham
Oct 1, 1980·European Journal of Immunology·E L ReinherzS F Schlossman
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L EvansR A Good
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L V JohnsonL B Chen
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Sep 1, 1980·The Journal of Experimental Medicine·N HollanderI L Weissman
Jan 1, 1981·The Journal of Experimental Medicine·M KamounR C Nowinski
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Aug 1, 1960·Archives of Biochemistry and Biophysics·A NISONOFFD L WOERNLEY

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Citations

Dec 18, 2001·European Journal of Immunology·T KambayashiH G Ljunggren
May 1, 1991·Arthritis and Rheumatism·D A FoxW J McCune
Jan 1, 1985·Human Genetics·G BrunsL A Herzenberg
Jan 1, 1989·Anatomy and Embryology·P Groscurth
Sep 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·K J Parlevliet, P T Schellekens
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D J Norman, M R Leone
May 1, 1984·Journal of Clinical Immunology·A WeissJ Stobo
Oct 1, 1991·Digestive Diseases and Sciences·S V McDiarmidR W Busuttil
Jan 1, 1989·Cancer Immunology, Immunotherapy : CII·D PeestH Deicher
Jan 1, 1984·Springer Seminars in Immunopathology·S F Schlossman, E L Reinherz
Jan 1, 1984·Springer Seminars in Immunopathology·C B Carpenter, T B Strom
Jan 1, 1996·Immunogenetics·O LecomteJ R Parnes
Mar 16, 1988·Journal of Immunological Methods·D KabelitzC Brucker
Apr 17, 1990·Journal of Immunological Methods·S R Riddell, P D Greenberg
Feb 1, 1987·Journal of the Neurological Sciences·S Starosta, G Birnbaum
May 1, 1984·Molecular Immunology·A F LópezI J Stanley
Nov 1, 1986·Molecular Immunology·S MeuerK H Meyer zum Büschenfelde
Aug 1, 1995·Molecular Immunology·M ExleyC Terhorst
Jul 1, 1996·Molecular Immunology·R MakidaD Y Leung
Jan 1, 1991·Veterinary Immunology and Immunopathology·J J Letesson, A Bensaid
Jan 1, 1985·Immunology Letters·A D Blann, M Salmon
Jun 1, 1986·Journal of Neuroimmunology·H J Schluesener
Jul 1, 1988·Immunology Today·P AndersonS F Schlossman
Mar 1, 1987·Human Immunology·H C Oettgen, C Terhorst
Aug 1, 2000·Journal of Immunological Methods·S M PatrickE F Leonard
Apr 12, 2002·Veterinary Immunology and Immunopathology·Aric N RogersCynthia L Baldwin
Feb 26, 2000·Human Immunology·J Jason, K L Inge
Jun 25, 1998·Current Opinion in Immunology·T Saito

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