Antigen recognition during progression from acute to chronic infection with a cagA-positive strain of Helicobacter pylori.

Infection and Immunity
H M MitchellD Frommer

Abstract

We have previously published two reports on acute infection with Helicobacter pylori, one of an adult male and one of a family of four. In the present study, we have isolated H.pylori from each of twin boys in the family and compared these by use of random amplified polymorphic DNA PCR. In addition, we have monitored the antibody response over time of the family and the adult male by Western blotting (immunoblotting) with two different strains of H. pylori as the antigen and by use of a commercial kit. The acutely infected twin boys were infected by an identical strain of H. pylori. The twin boys responded to antigens of 19, 26.5, and 29 kDa 30 days after the initial diagnosis, with recognition of 43-to 49-, 66-, 69-, and 87-kDa antigens by day 63. One twin responded to the CagA antigen on day 63, whereas the other responded on day 857. Antibody to the CagA antigen was not detected by use of the infecting strain, UNSW-RU1. Investigation of UNSW-RU1 revealed the presence of cagA. In two acutely infected adults (one, the father of the boys), the initial response to a 45-kDA antigen was later followed by responses to 19-, 29-, 49-, 60-, 77-, and 84-kDa antigens. Sera from the twins' younger sister, born 17 months after the twins a...Continue Reading

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Citations

Sep 3, 2002·Clinical and Diagnostic Laboratory Immunology·Günter BodeHermann Brenner
Sep 9, 1999·Journal of Clinical Gastroenterology·Y ElitsurC Neace
Mar 29, 2001·Irish Journal of Medical Science·N P BreslinC A O'Morain
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Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·H M MitchellY Y Li
Dec 7, 2002·European Journal of Gastroenterology & Hepatology·Katarzyna Dzierzanowska-FangratDanuta Dzierzanowska
Feb 29, 2000·The Pediatric Infectious Disease Journal·J RaymondC Dupont
Jun 6, 2017·Journal of Korean Medical Science·Ji Hyun SeoKwang Ho Rhee
Feb 17, 2001·Archives of Medical Research·J TorresO Muñoz
Nov 14, 1997·Infection and Immunity·F J RadcliffA Lee
Nov 17, 2021·Journal of Agricultural and Food Chemistry·Leheng ZhangSuqing Zhao

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