Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Anna VardiKostas Stamatopoulos

Abstract

The role of antigen(s) in shaping the T-cell repertoire in chronic lymphocytic leukemia, although relevant for understanding malignant cell interactions with cognate T cells, is largely unexplored. Here we profiled the T-cell receptor β chain gene repertoire in 58 chronic lymphocytic leukemia patients, focusing on cases assigned to well-characterized subsets with stereotyped clonotypic B-cell receptor immunoglobulins, therefore those cases most evidently selected by antigen (subsets #1, #2, and #4). Remarkable repertoire skewing and oligoclonality were observed, and differences between subsets were noted regarding both T-cell receptor β chain gene usage and the extent of clonality, with subset #2 being the least oligoclonal. Longitudinal analysis of subset #4 cases revealed that although the repertoire may fluctuate over time, certain clonotypes persist, thus alluding to persistent antigenic stimulation. Shared ("stereotyped") clonotypes were found between different patients, reflecting selection by common antigenic elements. Cross-comparison of our dataset with public databases showed that some T-cell clonotypes may have expanded secondary to common viral infections; however, the majority of clonotypes proved to be disease-spe...Continue Reading

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Citations

Jan 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingsong YinJan A Burger
Apr 19, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anton W LangerakUNKNOWN EuroClonality-NGS Consortium
Aug 15, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georg AueAdrian Wiestner
Apr 20, 2018·BMC Bioinformatics·Christos MaramisIoanna Chouvarda
Dec 22, 2019·International Journal of Molecular Sciences·Maissa MhibikClare Sun
May 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aliki XochelliKostas Stamatopoulos
Jul 4, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna VardiAnastasia Chatzidimitriou
Sep 26, 2020·Experimental Hematology·Paul J HengeveldAnton W Langerak
Feb 9, 2021·Frontiers in Immunology·Elisavet VlachonikolaAnastasia Chatzidimitriou
Dec 15, 2020·Frontiers in Immunology·Valentina GriggioMarta Coscia
May 12, 2021·Blood Cancer Journal·Yucai WangWei Ding
Jul 3, 2021·Cancers·Elisavet VlachonikolaAnastasia Chatzidimitriou

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