Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors.

Cancer Research
Youngshang PakByungkook Lee

Abstract

Recombinant immunotoxins (RIT) are targeted anticancer agents that are composed of a targeting antibody fragment and a protein toxin fragment. SS1P is a RIT that targets mesothelin on the surface of cancer cells and is being evaluated in patients with mesothelioma. Mesothelin, like many other target antigens, is shed from the cell surface. However, whether antigen shedding positively or negatively affects the delivery of RIT remains unknown. In this study, we used experimental data with SS1P to develop a mathematical model that describes the relationship between tumor volume changes and the dose level of the administered RIT, while accounting for the potential effects of antigen shedding.

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Citations

May 17, 2014·Expert Review of Anticancer Therapy·Sabina Antonela AntoniuDidona Ungureanu
Mar 18, 2016·EJNMMI Research·O Vilhelmsson TimmermandSe Strand
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May 10, 2019·Frontiers in Pharmacology·Haichao TangYing Jin
Nov 2, 2019·Journal of Pharmaceutical Sciences·Ji-Sun KimYong-Sung Kim
Aug 13, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quy LeSoheil Meshinchi

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