PMID: 9529081Apr 7, 1998Paper

Antigen-specific CD8+ T cells protect against lethal toxoplasmosis in mice infected with Neospora caninum

Infection and Immunity
Lloyd H Kasper, I A Khan

Abstract

Neospora caninum is a coccidial protozoan parasite that appears morphologically indistinguishable from Toxoplasma gondii and that infects a large range of mammals. Both inbred and outbred strains of mice exhibit a high degree of resistance to infection with N. caninum. Three inbred strains of mice (A/J, BALB/c, and C57BL/6) that were infected intraperitoneally with N. caninum were protected against a lethal challenge from T. gondii. Vaccine-induced protection was Neospora dose dependent. A rise in the CD8+ T-cell population in mice that had been vaccinated with N. caninum and challenged with T. gondii was observed. Adoptive transfer of CD8+ T-cell splenocytes from N. caninum-infected mice was protective against challenge with Toxoplasma. The CD8+ T cells from Neospora-infected mice proliferate to both Neospora and Toxoplasma antigens in vitro and secrete substantial quantities of gamma interferon when pulsed with the parasite antigen. These observations demonstrate that N. caninum protects against lethal T. gondii infection by the induction of CD8+ T cells that are immunoreactive to both parasites.

References

Jun 1, 1976·Experimental Parasitology·E R Pfefferkorn, L C Pfefferkorn
Sep 1, 1990·Veterinary Pathology·J P DubeyT P Lipscomb
Feb 1, 1990·Australian Veterinary Journal·B L MundayR W Mason
Dec 1, 1995·The Journal of Infectious Diseases·D K Howe, L D Sibley
Jun 1, 1994·The Journal of Experimental Medicine·L K SelinR M Welsh
Jan 1, 1997·Experimental Parasitology·I A KhanL H Kasper

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Citations

Jun 11, 2002·The Journal of Parasitology·Dianne M RitterDavid Brake
Jan 1, 2011·Animals : an Open Access Journal From MDPI·Thierry MonneyAndrew Hemphill
Feb 21, 2002·The Journal of Veterinary Medical Science·Yoshifumi NishikawaHideyuki Nagasawa
Aug 6, 2000·International Journal for Parasitology·A Hemphill, B Gottstein
Nov 27, 1999·International Journal for Parasitology·A HemphillA Hehl

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