PMID: 6167602Sep 1, 1981Paper

Antigen-specific densensitization in a rabbit model of acute hypersensitivity pneumonitis

The Journal of Allergy and Clinical Immunology
H B RichersonM T Suelzer

Abstract

Rabbits that had been prepared to develop acute alveolitis after aerosol challenge with simple protein antigens did not develop chronic alveolitis but rather gradually recovered despite continued challenge. Immunologic accompaniments of waning disease were compared in this model to those associated with intravenous injections of antigen causing "desensitization." We also studied the effects of aerosol challenge prior to systemic immunization, antigen specificity, and the duration of desensitization by aerosolized and intravenous antigen. We found that repeated aerosol or intravenous challenges produced antigen-specific desensitization in this model, and the effect lasted several weeks. Prior exposure to aerosolized antigen was not protective. Neither aerosol nor intravenous desensitization maneuvers abrogated antigen-specific lymphocyte blastogenesis, although an early transient fall did occur. Humoral responses were boosted. These findings suggest that chronic alveolitis is prevented in this model by specific desensitization, without the induction of true tolerance or of nonspecific anergy. Such immunoregulation may result from development of antigen-specific blockade or blocking factors (e.g., lymphokines), antigen-antibody c...Continue Reading

References

Jun 7, 1979·The New England Journal of Medicine·M SchatzJ Fink
Oct 1, 1979·Cellular Immunology·H V RatajczakH B Richerson
Jan 1, 1974·Annals of the New York Academy of Sciences·H B Richerson
May 29, 1980·The New England Journal of Medicine·R E RocklinK L Melmon
Dec 1, 1980·The Journal of Experimental Medicine·S J Challacombe, T B Tomasi

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Citations

Jan 1, 1990·American Journal of Industrial Medicine·H B Richerson
Mar 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J E Salvaggio
Apr 26, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tengku IsmailGavin Boyd
May 1, 1992·The American Review of Respiratory Disease·M R SchuylerT Merlin
Dec 1, 1992·The American Review of Respiratory Disease·M SchuylerL Crooks
Nov 1, 1991·American Journal of Respiratory Cell and Molecular Biology·H B RichersonD Lubaroff
Jan 1, 1982·Critical Reviews in Toxicology·R P StankusJ E Salvaggio
Jul 1, 1983·Clinical Allergy·C McSharryG Boyd
Jul 1, 1991·Disease-a-month : DM·O P Sharma

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