PMID: 6161200Dec 1, 1980Paper

Antigen-specific helper T cells required for dominant production of an idiotype (THId) are not under immune response (Ir) gene control

The Journal of Experimental Medicine
K Bottomly, P H Maurer

Abstract

Responder and nonresponder mice primed with poly-(L-glutamic acid,L-lysine,L-phenylalanine) (GLPhe), the response to which is under the control of immune response (Ir) genes, were used as a source of both types of helper T cells required for a T15 idiotype dominated T-dependent anti-phosphorylcholine (PC) response. It was found that the activity of one of the helper T cells needed for an anti-PC response was under major histocompatibility complex (MHC)-linked Ir gene control, and only GLPhe-primed responder mice could be used as a source of these cells. These T cells (ThMHC) whose presence is required for in vivo T-B collaboration are found in normal and anti-mu-treated mice, and their activity depends on the hapten being physically linked to the carrier molecule. By contrast, the activity of the second helper T cell (ThId) required for a T15-dominated anti-PC response was present in both GLPhe-primed responder and nonresponder mice. The ThId cell set that is missing or deficient in anti-mu treated mice can be restored by the addition of T cells from normal, carrier-primed donors and restimulating with the priming carrier. When T cells from GLPhe-primed donors are used as a source of ThId cells, both responder and nonresponder ...Continue Reading

References

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Citations

Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Bikoff
Aug 1, 1981·The Journal of Experimental Medicine·K Bottomly, D E Mosier
Sep 1, 1981·The Journal of Experimental Medicine·P LonaiG J Hämmerling
Nov 1, 1981·The Journal of Experimental Medicine·J FormanE S Vitetta
Jan 1, 1986·The Journal of Experimental Medicine·J P TiteC A Janeway
Jun 26, 2008·Acta Tropica·Iramaya Rodrigues CaldasGiovanni Gazzinelli
Nov 1, 1982·European Journal of Immunology·N A Speck, S K Pierce
Jan 1, 1983·Annals of the New York Academy of Sciences·S K Pierce, N A Speck
Jun 1, 1984·Immunological Reviews·K Bottomly
Jul 1, 1985·European Journal of Immunology·E Becker Dunn, K Bottomly

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