PMID: 6973603Aug 1, 1981Paper

Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted

The Journal of Experimental Medicine
K Bottomly, D E Mosier

Abstract

Two synergizing antigen-specific helper T (Th) cell populations are required for an optimal TEPC15 (T15)-dominated antiphosphorylcholine (PC) plaque- forming cell response . In these studies, the two Th cell sets are shown to differ in their requirements for recognition of self-major histocompatibility complex (MHC)-encoded determinants by testing the ability of Th cells from F(1) {arrow} parent bone marrow chimeras to collaborate with PC-specific B cells bearing MHC-encoded determinants of either parental haplotypes. Previous studies have shown that one antigen-specific Th cell population is required for T-dependent anti-PC responses and activates PC-specific B cells only if the hapten, PC, is physically linked to the priming antigen. This Th cell, referred to as ThMHC, induces anti-PC responses that are mainly non-T15 in character, and it appears to be identical to the conventional antigen- specific Th cell. In these experiments, using T cells from (A X B)F(1) {arrow} parent A chimeras, ThMHC cells requiring hapten-carrier association provide help for F(1) and parent A B cells but not for B cells from parent B, thus confirming that the activity of the conventional Th cell is H-2 restricted . The second antigen-specific Th cel...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH Wigzell

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Citations

Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Bikoff
May 1, 1982·The Journal of Experimental Medicine·P A Berche, R J North
Oct 1, 1982·Immunology Today·S Howie, W H McBride
Jun 1, 1985·European Journal of Immunology·K S HathcockR J Hodes
Jul 1, 1985·European Journal of Immunology·E Becker Dunn, K Bottomly
Jan 1, 1982·Immunological Reviews·Y J Rosenberg
Jun 1, 1982·European Journal of Immunology·A LanzavecchiaF Celada
Jan 1, 1982·Immunological Reviews·G DoriaL Adorini
Jun 30, 1983·Annals of the New York Academy of Sciences·M F Kagnoff
Jun 1, 1984·Immunological Reviews·K Bottomly

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