PMID: 6983073Nov 1, 1982Paper

Antigen-specific human T-cell hybridomas with helper activity

Proceedings of the National Academy of Sciences of the United States of America
E C DeFreitasC M Croce

Abstract

Human T cell hybridomas were produced by fusing the hypoxanthine phosphoribosyltransferase-deficient line of the human T cell lymphoma Jurkat with a continuous line of normal human T cells specific for tetanus toxoid (TeT). The hybridomas were selected for their ability to produce interleukin 2 after exposure to TeT on semiautologous monocytes and for their ability to bind to TeT-pulsed semiautologous monocytes. These antigen-specific T hybridomas demonstrated potent helper activity for semiautologous B cells as determined by the production of high levels of anti-TeT antibody in vitro.

References

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Citations

Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiH F Sears
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T F Huff, K Ishizaka
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A de la HeraC Martinez
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M WettendorffD Herlyn
Jun 18, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Zenon Steplewski, Thomas Kieber-Emmons
Aug 1, 1984·Cellular Immunology·C Y LauA Ishaque
Mar 1, 1988·Molecular and Cellular Probes·R I Lechler

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