Antigen-specific immunity. Th cell-dependent B cell responses

Immunologic Research
M G McHeyzer-WilliamsM D Eisenbraun

Abstract

Helper T cell-regulated B cell responses constitute a major component of the primary immune response to many pathogens. The subsequent development of antigen-specific immune memory is one critical outcome of this primary adaptive immune response. Antigen-specific immunity develops through a series of intercellular information exchanges organized around cognate T cell receptor-peptide/MHC interactions. Here, we discuss these complex molecularevents andtheircellularconsequences in a serial synapsis model of adaptive immunity. Our laboratory has developed strategies to isolate antigen-specific Th cells and B cells to analyze gene expression and cellular function in single responding lymphocytes directly ex vivo. These studies provide insight into the regulation and cellular organization of antigen-specific immune responses in vivo.

Citations

Jun 6, 2003·Current Opinion in Immunology·Michael G McHeyzer-Williams
Apr 12, 2003·Microbes and Infection·Michael McHeyzer-WilliamsMichael Eisenbraun
Jun 29, 2007·Molecular Biology of the Cell·Delphine Le RouxAna-Maria Lennon-Duménil
Jun 15, 2005·ILAR Journal·Kenneth C McCullough, Artur Summerfield
Nov 1, 2006·Expert Review of Clinical Immunology·Chang H Kim
Mar 29, 2007·The Journal of Cell Biology·Fulvia VascottoAna-Maria Lennon-Duménil
Oct 12, 2012·Biochimica Et Biophysica Acta·Joseph W Brewer
Sep 3, 2008·Parasite Immunology·W Harnett, M M Harnett
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessie F Fecteau, Sonia Néron
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharina RichardWenxia Song
Aug 10, 2019·Frontiers in Immunology·Jim Boonyaratanakornkit, Justin J Taylor
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanne M LumsdenRichard J Hodes
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olusegun O OnabajoWenxia Song

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