Antigen specific immunotherapy of multiple sclerosis

Journal of Clinical Immunology
Lawrence Steinman, P Conlon

Abstract

The development of antigen specific therapy for multiple sclerosis (MS) involves specifically suppressing undesired immune responses targeting the myelin sheath and underlying axon. We have recently reported some success with altered peptide ligands for a major target of the autoimmune response in MS. Antigen specific therapy has the potential to suppress undesirable autoimmunity, while leaving the rest of the immune system intact. Induction of an antigen specific Th1-to-Th2 shift could achieve this aim, once side effects, such as allergic responses, are minimized with optimal dosing.

Citations

Apr 18, 2003·Clinical and Experimental Immunology·L Adorini
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesco RiaLuciano Adorini
Oct 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajshekhar AlliTerrence L Geiger
Nov 28, 2012·Journal of Clinical Immunology·Honghao WangXueqiang Hu
Apr 28, 2010·Experimental Neurology·Angeliki GiannakopoulouGeorgios C Papadopoulos
Mar 30, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Piotr Cieplak, Alex Y Strongin
Jun 24, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Huihui YouXu Yang

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