Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4CD25 regulatory T cells

Scandinavian Journal of Immunology
S RaghavanJ Holmgren

Abstract

A Helicobacter pylori-specific in vitro coculture system was established and used to study the role of CD4+CD25+ regulatory T cells (Treg) in gastritis development in mice with H. pylori infection. Effects of therapeutic immunization against H. pylori infection on the Treg function were also studied to better understand the mechanisms leading to postimmunization gastritis in these mice. Depletion of Treg led to extensive proliferation to H. pylori antigens of CD4+ T cells isolated from either naïve, H. pylori-infected or H. pylori-immunized mice. Using the Treg-depleted CD4+ T cells from immunized mice as effector cells, we compared the suppressive efficacy of Treg isolated from naïve, infected or immunized mice and found that Treg from naïve mice, and slightly less efficiently from infected mice, suppressed the CD25- effector T-cell response and in most cases were distinctly more efficacious than Treg isolated from immunized mice. The suppressive efficacy of Treg isolated from the differently treated mice correlated closely with production of interleukin-5 (IL-5) by the Treg and suppression of interferon-gamma and IL-2 production by the CD25- effector T cells. Our study is the first to demonstrate in H. pylori-induced chronic ...Continue Reading

References

Apr 12, 2001·European Journal of Immunology·L A StephensF Powrie
Nov 28, 2001·Immunological Reviews·B SinghF Powrie
Jun 6, 2002·Immunology·Kajsa WingElisabeth Suri-Payer
Aug 21, 2002·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky

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Citations

Mar 24, 2005·Nature Immunology·Yasmine Belkaid, Barry T Rouse
Oct 24, 2006·Bone Marrow Transplantation·N T Le, N Chao
Aug 22, 2007·The Journal of Experimental Medicine·James P Scott-BrowneKevin B Urdahl
Jul 25, 2006·Infection and Immunity·Maureen L DrakesThomas G Blanchard
Mar 24, 2009·Annual Review of Immunology·Yasmine Belkaid, Kristin Tarbell
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Mathijs P Bergman, Mario M D'Elios
Dec 10, 2013·Hematology·Sung-Hsin Kuo, Ann-Lii Cheng
May 24, 2006·BMC Biotechnology·Iraldo Bello-RiveroPedro López-Saura
Dec 3, 2008·Pediatric Rheumatology Online Journal·Diana MilojevicElizabeth D Mellins
Nov 21, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masashi SakakiMichio Imawari
Dec 1, 2005·Scandinavian Journal of Immunology·Roland Jonsson
Nov 21, 2013·Gut Microbes·Shamila ZawahirThomas G Blanchard
Jan 1, 2014·Frontiers in Veterinary Science·Jonathan A RousseyPaul M Coussens
May 4, 2005·FEMS Immunology and Medical Microbiology·Sukanya Raghavan, Jan Holmgren
Jan 8, 2017·Archives of Pharmacal Research·Bonggoo ParkKyung-Mi Lee
Mar 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monica ViladomiuRaquel Hontecillas
Feb 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Steven J Czinn, Thomas Blanchard
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roniel CabreraDavid R Nelson
Jun 9, 2005·Clinical and Diagnostic Laboratory Immunology·Dean T NardelliRonald F Schell
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiaxiang JiLynn Soong
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fraser A MarshallMargaret M Harnett
Mar 11, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holly M Scott Algood
May 27, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sheng LiuYan Zhang
Aug 27, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hadi Maleki KakelarYadollah Omidi
Sep 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katina SchinnerlingThomas Schneider
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathleen M AndersonThomas G Blanchard
Mar 26, 2016·Veterinary Immunology and Immunopathology·Jonathan A RousseyPaul M Coussens

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