PMID: 15240673Jul 9, 2004Paper

Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling

The Journal of Immunology : Official Journal of the American Association of Immunologists
Carrie N ArnoldDaniel J Campbell

Abstract

Selective lymphocyte sequestration was described over 30 years ago as the transient withdrawal of Ag-specific lymphocytes from the circulation as a result of their activation in secondary lymphoid organs. We used a TCR-transgenic adoptive transfer system to further characterize the Ag and adjuvant dependence of this process in mice. In addition, we examined the contribution of the alpha(L) and alpha(4) integrin chains as well as Galpha(i) protein-coupled receptor signaling to the retention of Ag-specific T cells in peripheral lymph nodes. Our results demonstrate that selective lymphocyte sequestration is T cell autonomous and adjuvant independent, and that the duration of sequestration is not controlled by the continued presence of Ag in secondary lymphoid organs. This process is not critically dependent on the alpha(L) and alpha(4) integrin chains or Galpha(i) protein-coupled receptor signaling. Selective lymphocyte sequestration may be mediated by redundant mechanisms and/or controlled by novel or nonclassical adhesion or trafficking molecules.

References

Apr 1, 1976·The Journal of Experimental Medicine·R N CahillZ Trnka
Mar 1, 1991·The Journal of Experimental Medicine·K MiyakeP W Kincade
Sep 1, 1972·The Journal of Experimental Medicine·D A RowleyM E Smith
Apr 1, 1971·Cellular Immunology·J SprentG F Mitchell
Jan 10, 2002·The Journal of Experimental Medicine·Daniel J Campbell, Eugene C Butcher
Apr 30, 2002·Seminars in Immunology·Brent Johnston, Eugene C Butcher
May 22, 2002·The Journal of Experimental Medicine·Hiroyuki YoneyamaKouji Matsushima
Jun 8, 2002·Science·Sabine StollRonald N Germain
Jul 20, 2002·Science·Theresa T Lu, Jason G Cyster
Dec 7, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Markus Graeler, Edward J Goetzl
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Flavio Vincenti
Feb 5, 2003·The Journal of Experimental Medicine·Mirja Hommel, Bruno Kyewski
Jan 9, 2004·Nature·Thorsten R MempelUlrich H Von Andrian

❮ Previous
Next ❯

Citations

Jul 7, 2005·Nature Reviews. Immunology·Hugh Rosen, Edward J Goetzl
Jul 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liang ZhiMei X Wu
Aug 24, 2005·Nature Immunology·Gudrun F DebesEugene C Butcher
Sep 6, 2014·Nature Communications·Milas UgurOliver Pabst
Nov 15, 2018·Frontiers in Cell and Developmental Biology·Noa Beatriz Martín-CófrecesFrancisco Sánchez-Madrid
Apr 23, 2010·Immunology·Federica M Marelli-BergAlf Hamann
Jul 13, 2007·Immunological Reviews·Andrew SmithNancy Hogg
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oliver PabstReinhold Förster
Jan 2, 2009·Journal of Cell Science·Rachel EvansNancy Hogg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sravanthi Kandula, Clara Abraham
The Journal of Immunology : Official Journal of the American Association of Immunologists
Marissa MarskiClara Abraham
The Journal of Immunology : Official Journal of the American Association of Immunologists
James J CampbellMarc-André Wurbel
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Patrick BertolinoAlf Hamann
© 2022 Meta ULC. All rights reserved