PMID: 6965306Jan 1, 1980Paper

Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally

The Journal of Experimental Medicine
M H SchreierF Melchers

Abstract

Lipopolysaccharide (LPS)-activated B-cell blasts from C57BL/6J nu/nu spleen cells develop into IgM-secreting clones after stimulation by antigen-specific T-helper cells of C57BL/6J origin. Although induction of help is antigen-dependent, help itself acts polyclonally. 1 of 1--3 B-cell blasts is restimulated in a homologous fashion by LPS, or in a heterologous fashion by sheep erythrocyte (SRC)- or horse erythrocyte (HRC)-activated T-helper cells. The repertoire of activated B-cell blasts reflects the polyclonal nature of activation: approximately 1 in 1,000--3,000 restimulated B-cell blasts is specific for SRC, 1 in 300--1,000 is specific for HRC, and 1 in 100--300 specific for trinitrophenylated SRC (TNP30-SRC). B-cell blasts that are either H-2 compatible or H-2 incompatible with the antigen-activated T-cell help are stimulated polyclonally in similar high frequencies. Thus, neither antigen nor H-2 compatibility are required to stimulate a B-cell blast into the next cell cycle.

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Citations

Jan 1, 1988·Immunologic Research·J G Monroe, V L Seyfert
Jun 1, 1982·Veterinary Parasitology·L C Gasbarre, J F Urban
Mar 1, 1982·Immunobiology·M H SchreierM J van Zwieten
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J AnderssonF Melchers
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J Anderson, F Melchers
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J PaigeC L Sidman
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T LeandersonA Coutinho
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M H JuliusC L Sidman
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanL D Shultz
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N J LoCascioR B Corley
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G S HebbardG J Nossal
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R B CorleyG Haughton
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F Melchers, W Lernhardt
May 1, 1980·The Journal of Experimental Medicine·R B CorleyM A Cooley
Mar 1, 1993·The Veterinary Quarterly·P JolingA M Henken
Jan 1, 1983·Journal of Immunopharmacology·J A Teodorczyk-InjeyanL Makowka
Jul 1, 1984·Cell·F Melchers, J Andersson
Dec 1, 1985·Journal of Neurochemistry·A L De BlasC A Rayner
Feb 1, 1987·Scandinavian Journal of Immunology·M H JuliusJ C Cambier
Apr 1, 1984·Immunological Reviews·T KishimotoY Miki
Feb 1, 1987·Immunological Reviews·M H Julius
Oct 1, 1982·Scandinavian Journal of Immunology·C WoodG Möller
Jan 1, 1982·Scandinavian Journal of Immunology·J A Teodorczyk-InjeyanJ A Falk
Jan 1, 1982·Immunological Reviews·A L DeFrancoW E Paul
Nov 1, 1981·Immunology Today·N R KlinmanJ M Teale
Jan 1, 1984·Immunology Today·G G Klaus, C M Hawrylowicz
Nov 1, 2007·European Journal of Immunology·Fritz Melchers
Jul 1, 1986·European Journal of Immunology·A VazquezP Galanaud

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