PMID: 6166713May 1, 1981Paper

Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity

The Journal of Experimental Medicine
M FresnoH Cantor

Abstract

We have generated continuously propagatable T lymphocyte clones to study antigen-specific T cell functions. All Ly-2+ clones mediate suppressive activity and secrete a characteristic pattern of polypeptides that differs from Ly-2- T cell clones. Cells of one clone, Cl.Ly23/4, specifically bind glycophorin from sheep erythrocytes (SRBC). After incubation with [35S]methionine, supernate material from this clone also contains biosynthetically labeled 70,000-mol wt proteins that specifically bind to SRBC and this binding is inhibited by glycophorin from sheep but not other erythrocytes. These antigen-binding 70,000-mol wt peptides specifically and completely suppress primary anti-SRBC responses generated by mixtures of primed Ly-1+2- cells and B cells. Suppression by these antigen-binding peptides reflects direct inhibition of T-helper activity.

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Citations

Dec 1, 1994·Cancer Immunology, Immunotherapy : CII·D M Sahasrabudhe, J C Dusel
Feb 25, 1983·Journal of Immunological Methods·T M Folks, K W Sell
Feb 1, 1989·Veterinary Immunology and Immunopathology·L D PearsonJ C Demartini
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Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W L ClevelandB F Erlanger
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S K HuR K Gershon
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G J FreemanH Cantor
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R LifshitzE Mozes
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Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M M Abu-HadidG L Mayers
Dec 1, 1981·The Journal of Experimental Medicine·O IrigoyenL Chess
Aug 1, 1982·The Journal of Experimental Medicine·G NabelH Cantor
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May 1, 1985·Clinical Immunology and Immunopathology·A R Pachner, F S Kantor

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