PMID: 11312248Apr 20, 2001Paper

Antigen-specific T(h)1 cells as direct effectors of Propionibacterium acnes-primed lipopolysaccharide-induced hepatic injury

International Immunology
T OkazakiK Nakao

Abstract

T(h)1 cells are cytotoxic effector cells that utilize Fas ligand (FasL) and tumor necrosis factor. The physiological roles of cytotoxic T(h)1 cells are considered to be immunoregulation by eliminating autoreactive lymphocytes or hyper-activated foreign antigen-specific lymphocytes. Their pathological roles, however, remain to be clarified. To investigate whether T(h)1 cells can destroy organs, we generated a Propionibacterium acnes-specific T(h)1 clone from C57BL/6 mice and tested whether the clone could serve as an effector in a P. acnes-primed lipopolysaccharide (LPS)-induced hepatic injury system, one of the septic shock models. B6SMN:C3H-FasL(gld) (B6-gld) mice, which were deficient in functional FasL, were resistant to P. acnes/LPS-induced hepatic shock. The T(h)1 clone rendered B6-gld mice sensitive to the hepatic shock after the i.v. transfer. The hepatic injury in the clone-transferred B6-gld mice, which was evaluated by both biochemical and histological examination, was inhibited by an anti-FasL mAb that we developed. These results suggested that bacterial antigen-specific T(h)1 cells like this clone can participate in organ destruction in vivo as one of the cytotoxic effectors and play a critical role in endotoxin-ind...Continue Reading

References

Jun 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N KawadaS Morisawa
Jan 1, 1986·Cancer Immunology, Immunotherapy : CII·M KaufmannH Hvid-Hansen
Nov 17, 1995·Science·T S GriffithT A Ferguson
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S T JuA Marshak-Rothstein
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·S HanabuchiK Okumura
Oct 19, 1995·Nature·D BellgrauR C Duke
May 26, 1995·Science·J D KatzD Mathis
Sep 1, 1994·The Journal of Experimental Medicine·W P Fung-LeungC Y Lau
Oct 31, 1996·Nature·A K AbbasA Sher
Apr 4, 1997·Cell·A V ChervonskyL A Matis
Apr 1, 1997·Nature Medicine·T KondoS Nagata
Sep 8, 1999·The Journal of Experimental Medicine·T NishimuraA Ohta
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A OhtaT Nishimura

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Citations

Aug 13, 2002·Current Opinion in Pulmonary Medicine·David R Moller, Edward S Chen
Jan 8, 2004·The Journal of Investigative Dermatology·Paul E MouserAnthony C Chu
Oct 31, 2006·The Journal of Surgical Research·Atsuko FukazawaSatoshi Nakamura
Aug 7, 2010·European Journal of Immunology·Sandrine TchaptchetMarina A Freudenberg
Jan 27, 2021·Cellular and Molecular Gastroenterology and Hepatology·Wanlin YangWei Cai

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