PMID: 6161247Aug 1, 1980Paper

Antigenic analysis by immunofluorescence of in vitro-produced metacyclics of Trypanosoma brucei and their infections in mice

The Journal of protozoology
P R GardinerI Cunningham

Abstract

The antigenic types in populations of Metacyclic trypanosomes of Trypanosoma brucei isolated from Glossina morsitans head-salivary gland trypanosome cultures and bloodstream forms in the early parasitemias produced from whole culture supernatant fluids containing metacyclic forms, were analyzed by the indirect fluorescent antibody test using clone-specific antisera. Metacyclic trypanosomes in cultures initiated with cloned bloodstream forms with heterogeneous with respect to their variable antigenic type (VAT). Trypanosomes comprising early parasitemias in immunosuppressed mice infected with metacyclics produced in cultures also had a range of VATs. Three of the VATs detected in the early parasitemias in mice have also been identified by other investigators in tsetse fly-transmitted populations of the same stock.

References

Jan 1, 1975·Transactions of the Royal Society of Tropical Medicine and Hygiene·A R Gray
Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·J D BarryD Le Ray
Aug 1, 1979·The Journal of protozoology·I Cunningham, A M Taylor
Dec 1, 1970·Experimental Parasitology·S M Lanham, D G Godfrey
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J VaitukaitisG T Ross

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Citations

Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·T W JonesA R Gray
Feb 1, 1996·Tropical Animal Health and Production·R BoidA G Luckins
Apr 1, 1987·Acta Orthopaedica Scandinavica·G Lundborg

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