Antigenic and genetic diversity among swine influenza A H1N1 and H1N2 viruses in Europe

The Journal of General Virology
S MarozinA Hay

Abstract

Three subtypes of influenza A viruses, H1N1, H1N2 and H3N2, co-evolve in pigs in Europe. H1N2 viruses isolated from pigs in France and Italy since 1997 were closely related to the H1N2 viruses which emerged in the UK in 1994. In particular, the close relationship of the neuraminidases (NAs) of these viruses to the NA of a previous UK H3N2 swine virus indicated that they had not acquired the NA from H3N2 swine viruses circulating in continental Europe. Moreover, antigenic and genetic heterogeneity among the H1N2 viruses appeared to be due in part to multiple introductions of viruses from the UK. On the other hand, comparisons of internal gene sequences indicated genetic exchange between the H1N2 viruses and co-circulating H1N1 and/or H3N2 subtypes. Most genes of the earlier (1997-1998) H1N2 isolates were more closely related to those of a contemporary French H1N1 isolate, whereas the genes of later (1999-2000) isolates, including the HAs of some H1N2 viruses, were closely related to those of a distinct H1N1 antigenic variant which emerged in France in 1999. In contrast, an H3N2 virus isolated in France in 1999 was closely related antigenically and genetically to contemporary human A/Sydney/5/97-like viruses. These studies reveal...Continue Reading

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Citations

Jun 6, 2012·Journal of Virological Methods·Chiara ChiapponiEmanuela Foni
Nov 25, 2011·Veterinary Microbiology·Ana MorenoPaolo Cordioli
May 4, 2010·Molecular Phylogenetics and Evolution·Mathieu FourmentMark J Gibbs
May 8, 2010·Veterinary Microbiology·Porntippa LekcharoensukWilairat Chumsing
Apr 29, 2009·Veterinary Microbiology·Ana MorenoPaolo Cordioli
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Jun 16, 2007·Virus Research·Su Kyoung JoSang Heui Seo
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May 28, 2004·Virus Research·Y P LinA Hay
Sep 12, 2006·Veterinary Microbiology·Amy L VincentJuergen A Richt
Jun 29, 2014·The Journal of General Virology·Hyun-Mi KangYoun-Jeong Lee
Feb 19, 2009·The Journal of General Virology·Andi KrumbholzRoland Zell
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