Antigenic and genetic diversity of human enterovirus 71 from 2009 to 2012, Taiwan

PloS One
Yuan-Pin HuangHo-Sheng Wu

Abstract

Different subgenogroups of enterovirus 71 (EV-71) have caused numerous outbreaks of hand, foot, and mouth disease worldwide, especially in the Asia-Pacific region. During the development of a vaccine against EV-71, the genetic and antigenic diversities of EV-71 isolates from Taiwan were analyzed by phylogenetic analyses and neutralization tests. The results showed that the dominant genogroups had changed twice, from B to C and from C to B, between 2009 and 2012. The subgenogroup B5 (B5b cluster) was dominant in 2008-2009 but was replaced by subgenogroup C4 in 2010-2011. From the end of 2011 to 2012, the re-emerging subgenogroup B5 (B5c cluster) was identified as the dominant subgenogroup of EV-71 outbreaks, and subgenogroups C2 and C4 were detected in sporadic cases. Interestingly, the amino acid substitution at position 145 in the VP1 gene was observed in some strains isolated from patients with acute flaccid paralysis. Furthermore, thirty-five strains and their corresponding serum samples were used to analyze the cross-protections and antigenic diversities among different subgenogroups (C4a, C5, B4, B5b, B5c, and C2-like) of EV-71. Evident antigenic diversity existed only for the C2-like subgenogroup, which was not effectivel...Continue Reading

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Citations

Mar 4, 2014·Expert Review of Anti-infective Therapy·Shih-Min Wang, Ching-Chuan Liu
Sep 13, 2016·International Journal of Environmental Research and Public Health·Ping-Chin ChangKow-Tong Chen
Jan 14, 2017·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ting-Yu YenKao-Pin Hwang
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Feb 2, 2021·Frontiers in Microbiology·Chih-Shin ChangChiaho Shih
Dec 30, 2020·The Journal of Infection·Hanri ZengHui Li
May 21, 2021·Emerging Infectious Diseases·Kimberley S M BenschopPeter Simmonds

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Methods Mentioned

BETA
genotyping
proteotyping

Software Mentioned

Basic Local Alignment Search Tool ( BLAST )
GraphPad Prism
Molecular Evolutionary Genetics Analysis ( MEGA )
MEGA
SimPlot
BLAST
GraphPad

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