PMID: 16415996Jan 18, 2006

Antigenic and genetic study of hemagglutinin gene of influenza virus (H3N2) circulated in China in 2004

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
Yue-Long ShuYuanji Guo

Abstract

To study the antigenic and genetic characteristics of influenza (H3N2) virus circulated in China in 2004. Single-way and cross-way hemagglutination inhibition (HI) tests were firstly used to determine the reactivity with the reference serum of virus isolates. Based on the serological results, virus isolates were selected according to the different time and location in China in 2004. The HA1 domain of HA gene of those virus isolates were then sequenced in order to analyze the gene characterization. Single-way HI test results showed that 52.3% of isolates showed 4 folds or more HI titer difference compared to A/Fujian/411/2002 (H3N2) itself (international reference strain in 2004). Cross-way HI test results showed that the antigenic ratio was 4. The nucleic acid and amino acid sequence data of HA1 domain showed that the mutated virus appeared in early February of 2004, and became the dominant circulating strain gradually. There were four important mutant positions, they were 159 Y>F, 189 S>N, 145 K>N, 226 V>I, respectively. The results also indicated that the mutated viruses originated from southern China, then transmitted to northern China, according to the analysis of time and location distribution. The HA1 domain of HA gene of...Continue Reading

Related Concepts

Antibodies, Viral
Antigens, Viral
Phylogeny
RNA, Viral
Sequence Determinations, DNA
cDNA Probes
Reverse Transcriptase Polymerase Chain Reaction
Influenza A Virus, H3N2 Subtype

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