PMID: 9650935Jul 3, 1998Paper

Antigenic and molecular characterization of wild type 1 poliovirus causing outbreaks of poliomyelitis in Albania and neighboring countries in 1996

Journal of Clinical Microbiology
L FioreC Amato

Abstract

Mass vaccination has led poliomyelitis to become a rare disease in a large part of the world, including Western Europe. However, in the past 20 years wild polioviruses imported from countries where polio is endemic have been responsible for outbreaks in otherwise polio-free European countries. We report on the characterization of poliovirus isolates from a large outbreak of poliomyelitis that occurred in Albania in 1996 and that also spread to the neighboring countries of Yugoslavia and Greece. The epidemics involved 145 subjects, mostly young adults, and caused persisting paralysis in 87 individuals and 16 deaths. The agent responsible for the outbreak was isolated from 74 patients and was identified as wild type 1 poliovirus by both immunological and molecular methods. Sequence analysis of the genome demonstrated the involvement of a single virus strain throughout the epidemics, and genotyping analysis showed 95% homology of the strain with a wild type 1 poliovirus strain isolated in Pakistan in 1995. Neutralization assays with both human sera and monoclonal antibodies were performed to analyze the antigenic structure of the epidemic strain, suggesting its peculiar antigenic characteristics. The presented data underline the c...Continue Reading

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Citations

Apr 18, 2000·The Journal of General Virology·J SanttiT Hyypiä
May 29, 2004·The Journal of General Virology·Etem ÖzkayaShudo Yamazaki
Nov 16, 2004·Journal of Clinical Laboratory Analysis·Filanthi FrantzidouAntonis Antoniadis
Mar 26, 2013·Risk Analysis : an Official Publication of the Society for Risk Analysis·Radboud J Duintjer TebbensKimberly M Thompson
Aug 19, 2006·Canadian Journal of Microbiology·D N Pavlov
Sep 29, 2005·Acta Paediatrica·Maria BitsoriEmmanouil Galanakis
Nov 23, 2007·Journal of Applied Microbiology·E PaximadiP Markoulatos
Jul 15, 2005·American Journal of Epidemiology·Radboud J Duintjer TebbensKimberly M Thompson
Jul 31, 1999·Applied and Environmental Microbiology·M DiviziaA M Degener
Feb 13, 1999·Journal of Clinical Microbiology·A Arya
Mar 7, 2006·Journal of Clinical Microbiology·Zaharoula KyriakopoulouPanayotis Markoulatos
Jan 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F FrantzidouA Antoniadis

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