Antigenic and molecular heterogeneity of the transferrin-binding protein of Neisseria meningitidis

FEMS Microbiology Letters
E GriffithsA Ray

Abstract

The transferrin-binding protein in 35 Neisseria meningitidis isolates was examined using a binding assay involving 125I-transferrin. The results show that most strains have a binding protein with a Mr between 78 kDa and 83 kDa; only 4 strains had a binding protein with a Mr of about 68 kDa. The side of the protein appears unrelated to the serogroup or serotype of the organism. Using antibodies raised to whole cells of N. meningitidis grown under iron restriction we show also that considerable antigenic heterogeneity exists amongst the transferrin-binding proteins. This makes it a less than promising vaccine candidate antigen, although conserved antigenic domains are now being sought.

Citations

Jan 1, 1991·Biology of Metals·E Griffiths
Nov 1, 1993·FEMS Microbiology Reviews·K G Wooldridge, P H Williams
Jan 1, 1993·Research in Microbiology·M T CriadoC M Ferreirós
Jan 1, 1993·The Journal of Applied Bacteriology·A Robinson, J Melling
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Donna Perkins-BaldingIgor Stojiljkovic
Jun 2, 2009·Vaccine·Ian M Feavers, Mariagrazia Pizza
Jan 1, 1992·Critical Reviews in Microbiology·B R OttoD M MacLaren

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