PMID: 6168776Aug 1, 1981Paper

Antigenic and structural relationships of the surface antigens of hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis virus

Journal of Virology
M A FeitelsonW S Robinson

Abstract

The surface antigens of human hepatitis B (HBsAg), ground squirrel hepatitis (GSHsAg), and woodchuck hepatitis (WHsAg) viruses were compared serologically, and their major polypeptides were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and tryptic peptide mapping. Results showed that both GSHsAg and WHsAg are antigenically cross-reactive, that their major pairs of polypeptides have identical mobilities on sodium dodecyl sulfate gels, and that the major polypeptides of GSHsAg and WHsAg migrate faster in sodium dodecyl sulfate-polyacrylamide gel electrophoresis than do the corresponding bands of HBsAg. The peptide maps of the major (P-22) surface antigen polypeptides of GSHsAg and WHsAg showed that they shared over half of their spots. Peptide mapping of HBsAg subtypes indicated a close relationship between the major polypeptides (P-24) of adw and adr and a more distal relationship to ayw. Only about 25% of the spots shared by the combined HBsAg subtypes were also found in the peptide maps of GSHsAg and WHsAg, indicating at least some structural homology among the major polypeptides of the human and animal virus surface antigen particles. This is also reflected in the serological cross-reactivity among HBs...Continue Reading

References

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Citations

May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T I Michalak, N D Churchill
Sep 13, 2002·Journal of Medical Virology·Pedro BerraondoJuan Ruiz
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A Feitelson
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T I MichalakN D Churchill
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J Zuckerman
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P L MarionW S Robinson
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I MillmanC M Kang
Nov 19, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Pedro BerraondoGloria González-Aseguinolaza
Jul 1, 1996·Journal of Virology·P TestutM A Buendia
Feb 1, 1982·Infection and Immunity·I MillmanH Simmons
Nov 1, 1983·Journal of Virology·P L MarionW S Robinson

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