Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate.

Analytical Biochemistry
Adam V WisnewskiCarrie A Redlich

Abstract

Diphenylmethane diisocyanate (MDI), the chemical commonly used as a cross-linking agent in commercial polyurethane production, is a well-recognized cause of asthma. Reaction products between MDI and "self" proteins are hypothesized to act as antigens capable of inducing airway inflammation and asthma; however, such MDI antigens remain incompletely understood. We used a variety of analytical methods to characterize the range of MDI-albumin reaction products that form under physiological conditions. Sites of MDI conjugation on antigenic MDI-albumin products, as defined by serum immunoglobulin G (IgG) from MDI-exposed workers, were determined by high-performance liquid chromatography (HPLC) followed by tandem mass spectrometry (MS/MS). The data identified 14 MDI conjugation sites (12 lysines and 2 asparagines) on human albumin and highlight reaction specificity for the second lysine in dilysine (KK) motifs, and this may be a common characteristic of "immune-sensitizing" chemicals. Several of the MDI conjugation sites are not conserved in albumin from other species, and this may suggest species differences in epitope specificity for self protein (albumin)-isocyanate conjugates. The study also describes new applications of contempor...Continue Reading

References

Jun 21, 1978·Biochimica Et Biophysica Acta·J T GerigJ D Reinheimer
Jan 1, 1989·The Journal of Allergy and Clinical Immunology·U Wass, L Belin
Sep 1, 1988·Chemical Research in Toxicology·R Z Jin, M H Karol
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Awad-Elkarim, G E Means
Feb 1, 1983·The Journal of Allergy and Clinical Immunology·X Baur
Aug 1, 1996·International Archives of Allergy and Immunology·X BaurM Raulf-Heimsoth
Dec 24, 1997·Molecular Biotechnology·K R Williams, K L Stone
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·A V WisnewskiC A Redlich
Jun 1, 2001·American Journal of Industrial Medicine·C A RedlichM R Cullen
Jan 29, 2002·International Immunopharmacology·Carrie A Redlich, Meryl H Karol
May 30, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Qing Liu, Adam V Wisnewski
Jun 23, 2004·The Journal of Allergy and Clinical Immunology·Adam V WisnewskiCarrie A Redlich
Jul 28, 2004·Journal of the American Society for Mass Spectrometry·Bill X HuangChhabil Dass
Oct 13, 2006·The Journal of Allergy and Clinical Immunology·Young-Min YeAdam V Wisnewski
Oct 25, 2006·International Archives of Occupational and Environmental Health·A RobertP Marsan
Feb 24, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maja AleksicAnne Dell
Mar 14, 2007·Current Opinion in Allergy and Clinical Immunology·Adam V Wisnewski
Jul 28, 2007·American Journal of Respiratory and Critical Care Medicine·Anjoeka PronkDick Heederik
Aug 19, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gabriele SabbioniRichard Rumler
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A V WisnewskiC A Redlich
May 30, 2009·Journal of the American Society for Mass Spectrometry·Justin M HettickPaul D Siegel

❮ Previous
Next ❯

Citations

May 1, 2012·International Archives of Occupational and Environmental Health·Lygia Therese BudnikXaver Baur
Nov 28, 2012·Chemical Research in Toxicology·Gabriele SabbioniAnoop Kumar
Jul 26, 2011·Journal of Allergy·Itai ChipindaPaul D Siegel
Oct 22, 2011·International Journal of Environmental Research and Public Health·Annette Fisseler-EckhoffJoachim Schirren
Dec 23, 2015·Journal of Immunological Methods·Adam V Wisnewski, Jian Liu
Dec 19, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Adam V WisnewskiAla F Nassar
Jul 22, 2014·Journal of Applied Toxicology : JAT·Aristo VojdaniPartha Sarathi Mukherjee
Dec 31, 2011·Analytical Biochemistry·Justin M HettickAdam V Wisnewski
Jan 11, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gabriele SabbioniLakshiminiranjan Reddy Vanimireddy
Nov 28, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Adam V WisnewskiPaul D Siegel
Jun 25, 2013·Chemico-biological Interactions·Adam V WisnewskiCarrie A Redlich
Dec 19, 2016·Chemical Research in Toxicology·Gabriele Sabbioni, Robert J Turesky
Jun 21, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Justin M HettickPaul D Siegel
Jun 16, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A V Wisnewski, M Jones
Apr 18, 2020·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Adam V Wisnewski, Jian Liu
Jun 18, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gabriele SabbioniAnoop Kumar
May 11, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Adam V WisnewskiAla F Nassar
Sep 3, 2020·Chemical Research in Toxicology·Lorena NdreuIsabella Karlsson
Mar 5, 2020·The World Allergy Organization Journal·Ignacio J AnsoteguiTorsten Zuberbier
Feb 7, 2019·Chemical Research in Toxicology·Adam V WisnewskiDhimiter Bello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

The Journal of Allergy and Clinical Immunology
Adam V WisnewskiCarrie A Redlich
Journal of the American Society for Mass Spectrometry
Justin M HettickP D Siegel
American Journal of Respiratory and Critical Care Medicine
Adam V WisnewskiCarrie A Redlich
© 2021 Meta ULC. All rights reserved