Antigenic cross-reaction between the alpha types of human and mouse interferon

Antiviral Research
Y KawadeK Paucker

Abstract

Cross-neutralization of the alpha and beta types of human and mouse interferons was tested using antibodies directed against the heterologous types of interferons. The alpha type of mouse interferon (MuIFN-alpha) prepared from L cells was found to be completely neutralizable by high-titered antibody against human alpha-type interferon (HuIFN-alpha), although the titers were much lower than those obtained in neutralization reactions with the homologous interferon. MuIFN-alpha from virus-induced lymphocytes, as well as non-glycosylated MuIFN-alpha from L cells, reacted similarly. The cross-reaction was also observed by the binding of anti-HuIFN-alpha antibody to a column of immobilized MuIFN-alpha. The binding experiment indicated that only a small fraction of the anti-HuIFN-alpha antibody population is heterologous reactive. Reciprocally, HuIFN-alpha from L cells, again with relatively low antibody titers, and the antibody responsible for the heterologous reaction was shown to be the anti-MuIFN-alpha and not anti-MuIFN-beta type. It is concluded that the alpha types of human and mouse interferon bear an antigenic homology. On the other hand, no significant antigenic cross-reactivity has been detected between the beta types of hu...Continue Reading

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·K PauckerE Törmä
Jun 2, 1977·The New England Journal of Medicine·G Wadell
Jul 1, 1977·Antimicrobial Agents and Chemotherapy·A BilliauP De Somer
Apr 1, 1974·The Journal of General Virology·Y YamamotoY Kawade
Jul 10, 1980·Nature
Jun 1, 1980·Gene·T TaniguchiM Muramatsu
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L A PickeringW E Stewart
Jan 1, 1980·Annals of the New York Academy of Sciences·K Paucker, B J Dalton
Jan 1, 1980·Annals of the New York Academy of Sciences·Y KawadeY Watanabe
Mar 1, 1964·The Journal of Allergy·S O FREEDMAN

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Citations

Aug 1, 1982·Antiviral Research·Y KawadeM G Tovey
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y WatanabeT Sakata
Jan 1, 1983·Journal of Interferon Research·E A Havell, G L Spitalny
Jan 1, 1984·Journal of Interferon Research·H MachidaY Watanabe
Jan 1, 1984·Journal of Interferon Research·D M Murasko, E P Blankenhorn
Feb 11, 1983·Nucleic Acids Research·G D ShawC Weissmann
Jan 28, 1999·Biochemical and Biophysical Research Communications·S OkamotoM Hashida

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