Antigenic differences between the membrane antigen polypeptides determined by different EB virus isolates

The Journal of General Virology
S M FranklinM A Epstein

Abstract

The antigenic specificities of the membrane antigen (MA) complex of three Epstein-Barr (EB) virus-producing cell lines have been compared by complete absorption of an anti-MA antiserum with P3HR-1 cells, followed by testing for residual anti-MA antibody activity against B95-8 and QIMR-WIL cells. Indirect membrane immunofluorescence showed that the absorbed serum, which had lost the capacity to bind P3HR-1 cells, nevertheless gave bright staining on a small proportion of B95-8 cells. SDS-polyacrylamide gel electrophoretic analysis of 125I-labelled MA polypeptides showed that the absorbed serum was able to isolate MA polypeptides from both B95-7 and QIMR-WIL cells, but not from P3HR-2 cells. The results demonstrate that there is substantial sharing of antigenic specificities between the MA determined by three isolates of EB virus, and some antigenic divergence.

Citations

Sep 1, 1982·Journal of Virological Methods·J R NorthM A Epstein
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J R NorthM A Epstein

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