PMID: 2416864Jan 1, 1986Paper

Antigenic domains of the streptococcal Pep M5 protein. Localization of epitopes crossreactive with type 6 M protein and identification of a hypervariable region of the M molecule

The Journal of Experimental Medicine
B N ManjulaV A Fischetti

Abstract

Pep M5, the pepsin-derived N-terminal half of the group A streptococcal type 5 M protein exhibits immunologic crossreaction with type 6 M protein, localizing some of the M6-crossreactive epitope(s) within this segment of the M5 protein. Based on the amino acid sequence of the Pep M5 protein, two structurally distinct domains have been recognized within its coiled-coil structure. We have now found that peptides derived from both the structurally distinct domains of the Pep M5 protein contain antigenic epitopes. Furthermore, only the peptides from the C-terminal domain of the Pep M5 protein crossreacted with rabbit anti-M6 sera, whereas those from the N-terminal domain did not. Consistent with this, sequence analyses of the arginyl peptides of the Pep M6 protein, the pepsin-derived N-terminal half of the M6 protein, revealed extensive homology of some of these peptides with regions within the C-terminal domain of the Pep M5 molecule. While an arginyl peptide of the Pep M6 protein exhibits 84% homology with region 150-186 of the Pep M5 protein, the C-terminal hexadecapeptide of the Pep M6 protein is virtually identical with the corresponding region of the Pep M5 protein. These results are suggestive of conformational similarities ...Continue Reading

References

Mar 1, 1985·The Journal of Experimental Medicine·K F JonesV A Fischetti
Nov 1, 1971·The Journal of Experimental Medicine·J RottaH Lackland
Apr 1, 1972·The Journal of Infectious Diseases·S Bergner-RabinowitzM D Moody
May 28, 1969·Journal of Molecular Biology·S LoweyH Baker
Nov 1, 1969·The Journal of Experimental Medicine·J SwansonE C Gotschlich
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G N PhillipsV A Fischetti

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Citations

Sep 1, 1988·European Journal of Epidemiology·B N Manjula
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard F FacklamBernard Beall
Nov 22, 2011·Emerging Infectious Diseases·Patrick R SheaJames M Musser
Apr 4, 2012·Emerging Infectious Diseases·Nahuel FittipaldiJames M Musser
Feb 24, 2015·Diagnostic Microbiology and Infectious Disease·Jae Hong ChoiHoan Jong Lee
Oct 30, 1986·Biochemical and Biophysical Research Communications·B N Manjula, V A Fischetti
Mar 22, 2014·Journal of Clinical Microbiology·Taryn B T AtheyNahuel Fittipaldi
Mar 1, 2013·Emerging Microbes & Infections·Nahuel FittipaldiJames M Musser
May 22, 2018·Open Forum Infectious Diseases·Sarah TeateroNahuel Fittipaldi
Nov 27, 2020·Microbiology and Molecular Biology Reviews : MMBR·Gunnar Lindahl
Jul 1, 1989·Clinical Microbiology Reviews·V A Fischetti
Mar 1, 1990·Infection and Immunity·J B DaleD Schifferli

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