Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016

Influenza and Other Respiratory Viruses
Marcus J BoltonAmy L Vincent

Abstract

Six amino acid positions (145, 155, 156, 158, 159, and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of hemagglutinin (HA1 domain) play an important role in defining the antigenic phenotype of swine Clade IV (C-IV) H3N2 IAV, containing an H3 from a late 1990s human-to-swine introduction. We hypothesized that antigenicity of a swine C-IV H3 virus could be inferred based upon the antigenic motif if it matched a previously characterized antigen with the same motif. An increasing number of C-IV H3 genes encoding antigenic motifs that had not been previously characterized were observed in the U.S. pig population between 2012 and 2016. A broad panel of contemporary H3 viruses with uncharacterized antigenic motifs was selected across multiple clades within C-IV to assess the impact of HA1 genetic diversity on the antigenic phenotype. Hemagglutination inhibition (HI) assays were performed with isolates selected based on antigenic motif, tested against a panel of swine antisera, and visualized by antigenic cartography. A previously uncharacterized motif with low but sustained circulation in the swine population demonstrated a distinct phenotype from those previously characterized. Antigenic variation...Continue Reading

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Dec 8, 2016·Veterinary Microbiology·Amy L VincentNicola S Lewis

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Citations

Feb 27, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Aditi SharmaPhillip C Gauger
Mar 19, 2020·Transboundary and Emerging Diseases·Jayaveeramuthu NirmalaMontserrat Torremorell
Jul 12, 2020·Transboundary and Emerging Diseases·Fabian O Chamba PardoMontserrat Torremorell
Jan 29, 2020·Cold Spring Harbor Perspectives in Medicine·Tavis K AndersonAmy L Vincent
Jan 18, 2022·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ravendra P Chauhan, Michelle L Gordon

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