PMID: 1194854Dec 1, 1975Paper

Antigenic properties of cultured tumor cell lines derived from spleens of Friend virus-infected BALB/c and BALB/c-H-2b mice

The Journal of Experimental Medicine
H A FreedmanR Steeves

Abstract

BALB/c-H-2b (BALB.B) mice are less susceptible to the Friend virus (FV) disease syndrome than congenic BALB/c (H-2d) mice, and spleen cells from FV-infected BALB.B mice are markedly less tumorigenic on transplantation to syngeneic hosts than those from FV-infected BALB/c mice. For these reasons we investigated the expression of FV-associated cell surface antigens on cultured, FV-trnasformed cell lines of BALB.B and BALB/c origin. Both cell lines induced transplantation immunity in syngeneic hosts toward further implantations of the same tumor, BALB.B cells being significantly more potent in this respect than BALB/c cells. BALB.B tumor cells, which produce complete, infectious FV, expressed both the cell surface antigen, FMR (corresponding to the cytotoxic antibodies in anti-FV antisera), and virus envelope antigen (VEA, corresponding to the virus-neutralizing antibodies in the anti-FV antisera). BALB/c tumor cells, on the other hand, which are FV-nonproducers, expressed no FMR antigen, but did express VEA on their surfaces for at least 100 passages in culture. These cells could induce FV-neutralizing but not cytotoxic anti-FMR antibodies when used to immunize syngeneic hosts. The absence of FMR antigen may be the basis for the ...Continue Reading

References

Jul 1, 1975·The Journal of Experimental Medicine·H A Freedman, F Lilly
Apr 29, 1974·Biochimica Et Biophysica Acta·F Lilly, R Steeves
May 15, 1967·International Journal of Cancer. Journal International Du Cancer·R A Steeves, A A Axelrad

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Citations

Jun 1, 1988·Trends in Ecology & Evolution·K D Bennett, H F Lamb
Jan 1, 1977·Scandinavian Journal of Immunology·J E BubbersF Lilly
Nov 1, 1976·Virology·M Strand, J T August
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·K S Chang, T Log

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