PMID: 10436653Aug 7, 1999Paper

Antigenic relatedness of selected flaviviruses: study with homologous and heterologous immune mouse ascitic fluids

Revista Do Instituto De Medicina Tropical De São Paulo
S S BabaO D Olaleye

Abstract

The antigenic relationship of 9 flaviviruses, Yellow fever (YF), Wesselsbron (WSL), Uganda S (UGS), Potiskum (POT), West Nile (WN), Banzi (BAN), Zika (ZK), Dengue type 1 (DEN-1) and Dengue type 2 (DEN-2), was assessed by cross-haemagglutination-inhibition (Cross-HI) and cross-complement fixation (Cross-CF) reactions between each of the viruses and their homologous immune mouse ascitic fluids. Titre ratios were calculated using the heterologous and homologous titres. Cross-CF reactions revealed wider antigenic variations among viruses than Cross-HI reactions. There was no significant antigenic variation between WSL, POT and YF viruses using either of those methods. However, definite differences in antigenicity were observed between them and UGS, BAN and ZK viruses. There were no significant differences between UGS, BAN and ZK or between DEN-1 and DEN-2. The serological relationship among flaviviruses is important in establishing diagnosis and epidemiology of these infections in Africa.

References

Apr 1, 1974·The Journal of General Virology·A T De Madrid, J S PORTERFIELD
Jan 1, 1970·The American Journal of Tropical Medicine and Hygiene·B E HendersonM Lule
Mar 1, 1966·The American Journal of Tropical Medicine and Hygiene·E S TikasinghW G Downs
Jan 1, 1984·The American Journal of Tropical Medicine and Hygiene·T P Monath, R R Nystrom
Jul 1, 1981·The American Journal of Tropical Medicine and Hygiene·O TomoriC B Cropp
Sep 1, 1958·The American Journal of Tropical Medicine and Hygiene·D H CLARKE, J CASALS
Mar 1, 1959·Transactions of the Royal Society of Tropical Medicine and Hygiene·F N MACNAMARAJ S PORTERFIELD

Citations

Jan 27, 2007·BMC Bioinformatics·Asif M KhanV Brusic
Jan 27, 2010·Virology Journal·Francisca Sosa-JuradoJulio Reyes-Leyva
Jul 9, 2016·Trends in Microbiology·Kenneth Kim, Sujan Shresta
Jun 1, 2016·PloS One·Lisa A Waddell, Judy D Greig

Related Concepts

Antibodies, Viral
Antigenic Diversity
Antigens, Viral
Peritoneal Fluid (Body Substance)
Complement Fixation Tests
Cross Reactions
Flavivirus
Hemagglutination Inhibition Tests

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.