PMID: 46239Jan 1, 1975

Antigenic relationship between the fourth component of human and guinea pig complement

The Journal of Immunology : Official Journal of the American Association of Immunologists
S H Ohanian, T Borsos

Abstract

Antigenic similarity between cell-bound human and guinea pig C4 was detected with antisera specific for each of these molecules. No cross-reaction could be detected between C4 of normal guinea pig or human sera or after treatment of the sera with antigen-antibody C1 complexes. The cross-reactivity between cell-bound human and guinea pig C4 may reflect conformational changes in the C4 molecule as a result of binding of the cell surface.

Related Concepts

Immunoelectrophoresis
Cavia
Complex (molecular entity)
Antigenic Specificity
Immune Sera
Cross Reactions
Phosphoglycerate Dehydrogenase Activity
Hemolytic Complement
Forssman Antigen
Antigens

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