PMID: 13935673Jan 1, 1963

Antigenic relationships of Bence Jones proteins, myeloma globulins, and normal human gama-globulin

The Journal of Experimental Medicine
S MIGITA, F W PUTNAM

Abstract

By means of immunodiffusion and immunoelectrophoresis study has been made of antigenic relationships of Bence Jones proteins, and the three classes of normal and pathological immunoglobulins, 7S gamma, beta(2A), and beta(2M). All thirty-nine Bence Jones proteins studied could be classified into either one of two distinct antigenic types, A or B. Both types are related to the immunoelectrophoretically slow (S) fragment of a papain digest of normal gamma-globulin; B is related more closely than A, but neither has antigenic determinants in common with the fast (F) fragment. The 7S gamma myeloma globulins were either immunological type I or II. The papain digests of these proteins produced the S and F precipitin lines in immunoelectrophoresis but multiple bands in starch gel electrophoresis, especially in the F region. The S fraction of type I myeloma globulins is antigenically similar to Bence Jones protein of type B, and the S component of type II myeloma globulins has antigenic determinants in common with type A Bence Jones protein. Correspondingly, myeloma patients with type I globulins and proteinuria usually excrete type B Bence Jones proteins, whereas patients with type II excrete type A proteins. The F fragment is the part ...Continue Reading

References

Jan 1, 1956·Cancer·L KORNGOLD, R LIPARI
Oct 1, 1957·The Journal of Experimental Medicine·L Korngold, G VAN LEEUWEN
Dec 1, 1960·The Journal of Clinical Investigation·E C FRANKLIN
Jul 1, 1960·The Journal of Clinical Investigation·G T STEVENSON
May 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·F MEYER

Citations

Feb 1, 1969·Blut·M Eulitz
Feb 1, 1975·Bruxelles médical·J P Gassée, H M Brems
Apr 1, 1964·Immunochemistry·S J SINGER
Mar 1, 1977·Immunochemistry·D W Lehman, F W PUTNAM
Sep 28, 1963·Nature·O SMITHIES
Apr 9, 1966·Nature·M D POULIK
Sep 22, 1966·The New England Journal of Medicine·C A AlperC A Janeway
Nov 1, 1963·The Journal of Experimental Medicine·M MANNIK, H G KUNKEL
Mar 1, 1968·The Journal of Experimental Medicine·C Mihaesco, M Seligmann
Mar 1, 1966·British Journal of Haematology·R van FurthW Hijmans
Jan 1, 1964·The Journal of Clinical Investigation·A SolomonA S MCFARLANE
Jan 1, 1964·The Journal of Clinical Investigation·D GROSS, W V EPSTEIN
Feb 1, 1989·Scandinavian Journal of Immunology·M D BensonG Wheeler
Jan 17, 2016·Immunology Letters·Domenico Ribatti
Mar 1, 1964·Archives of Biochemistry and Biophysics·E C FRANKLIN, H H Fudenberg
Aug 1, 1964·The American Journal of Medicine·A Solomon, J L FAHEY
Jan 1, 1970·International Journal of Protein Research·C J Brackenridge
Jan 1, 1966·Acta Medica Scandinavica. Supplementum·C A Alper
Apr 15, 1971·Klinische Wochenschrift·A Fateh-MoghadamB Tsirimbas
May 1, 1967·Klinische Wochenschrift·F Bläker, K Fischer
Jan 1, 1966·Acta Medica Scandinavica. Supplementum·F W PUTNAMC W EASLEY
Jun 30, 1965·Annals of the New York Academy of Sciences·E C FRANKLIN, H H Fudenberg
Feb 28, 1964·Annals of the New York Academy of Sciences·G BRECHERJ L FAHEY
Sep 6, 1969·The Medical Journal of Australia·N L Warner

Related Concepts

Antigens
Bence Jones Protein SUT
Gamma globulin
Multiple Myeloma
Pseudoglobulins

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