Antigenic similarity between the protein neurotoxin alpha-bungarotoxin and neuromuscular blocking drugs

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D G HarleM M Fisher

Abstract

The snake neurotoxins alpha-bungarotoxin (alpha-BGT) and beta-bungarotoxin (beta-BGT) which act at the neuromuscular junction, were found to bind to IgE antibodies directed against neuromuscular blocking (NMB) drugs in the sera of two patients who had experienced lifethreatening anaphylactic reactions to succinylcholine. alpha-BGT inhibited IgE-binding to a choline-Sepharose solid support in one patient better than the NMB drug alcuronium, choline, triethylcholine and beta-BGT. IC50s for alpha-BGT and succinylcholine were 16 and 10 nmol respectively for one patient and 34 and 6.0 nmol for the other. Recognition of the NMB drugs and alpha-BGT by the same antibody is the first demonstration of an antigenic similarity between these drugs and the protein toxin.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D Tsernoglou, G A Petsko
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B W LowJ S Richardson
Jan 1, 1985·Annales Françaises D'anesthèsie Et De Rèanimation·B A BaldoM M Fisher
Jan 1, 1972·Annual Review of Pharmacology·C Y Lee
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J PatrickJ H Steinbach
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A J SytkowskiM W Nirenberg
Nov 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·P Lesca, C Paoletti
Feb 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·D MebsC Y Lee
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J P ChangeuxC Y Lee
Jan 1, 1954·Advances in Protein Chemistry·M LASKOWSKI, M LASKOWSKI

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Citations

Mar 12, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·L GuillouxE Beaudouin

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.