Abstract
Of the known neutralizing antigenic sites of foot-and-mouth disease virus (FMDV), site 1 or A, formed in part by the G-H loop of VP1, has historically been considered immunodominant because of evidence implicating its importance in the induction of a protective immune response. However, no systematic study has been done to determine the relative importance of the various specificities of antibodies against the known neutralizing antigenic sites of FMDV in the polyclonal immune response of a natural host after vaccination. In this report, we have adopted a monoclonal antibody-based competition ELISA and used antibodies specific to sites 1, 2 and 3 to provide some insight into this issue. Following vaccination of the three main target species, cattle, pigs and sheep, with an O1 serotype strain, results indicate that none of these three antigenic sites can be considered immunodominant in a polyclonal serum. Interestingly, pigs did not respond to epitopes on the carboxy terminus end of VP1 as efficiently as the ruminant species. In addition to the known sites, other as yet undefined sites might also be important in the induction of a protective immune response. Possible implications for the design of new vaccine strategies for foot...Continue Reading
References
Dec 1, 1992·The Journal of General Virology·D FeigelstockE L Palma
Mar 1, 1990·The Journal of General Virology·M G MateuE Domingo
Nov 1, 1990·Virology·J D KitsonG J Belsham
Aug 1, 1991·Vaccine·A L BrownB E Clarke
Apr 1, 1987·Virology·K C McCulloughD McCahon
Jan 1, 1988·Archives of Virology·A A ThomasR H Meloen
Aug 1, 1988·Journal of Virology·A A ThomasS J Barteling
May 1, 1989·Journal of Virology·B BaxtD O Morgan
Jun 1, 1989·The Journal of General Virology·P V BarnettN R Parry
Oct 1, 1988·Vaccine·R P KitchingN P Ferris
May 2, 1986·Science·R DiMarchiN Mowat
Mar 1, 1987·Vaccine·T W Pay, P J Hingley
Apr 1, 1969·The Journal of General Virology·T F WildF Brown
Apr 1, 1982·The Journal of General Virology·K StrohmaierK H Adam
Dec 4, 1981·Science·D G KleidH L Bachrach
Jul 1, 1982·Nature·J L BittleF Brown
Jan 10, 1995·Virology·M G MateuE Domingo
Aug 1, 1993·The Journal of General Virology·J R CrowtherA R Samuel
Sep 1, 1995·Virus Research·M G Mateu
Jan 6, 1997·Virology·P W MasonM J Grubman
Apr 1, 1997·Journal of Virology·O TabogaE L Palma
Oct 6, 1997·Journal of Virology·G WardP W Mason
Mar 12, 1998·Virus Research·G Butchaiah, D O Morgan
Jul 29, 1998·The Journal of General Virology·P V BarnettR M Parkhouse
Jul 31, 1998·Virology·C S DunnJ Anderson
Jun 12, 1999·Virology·A Sanz-ParraV Ley
Nov 2, 1999·Virology·G A MayrM J Grubman
Jan 11, 2000·Revue Scientifique Et Technique·S Aktas, A R Samuel
Mar 20, 2001·Veterinary Research·F SobrinoV Ley
Sep 21, 1963·Nature·F BROWN, B CARTWRIGHT
Citations
Jan 7, 2016·Virus Research·Bo YangHong Yin
Mar 8, 2013·Research in Veterinary Science·R RajasekharRamamurthy Venkataramanan
Apr 17, 2009·Vaccine·M M HarmsenP L Eblé
Jan 27, 2009·Veterinary Microbiology·Yimei CaoZaixin Liu
Nov 23, 2006·Veterinary Microbiology·José Júnior F BarrosIngrid E Bergmann
Dec 14, 2011·The Journal of General Virology·M MahapatraD J Paton
Jan 5, 2011·Virus Research·Daria A RutkowskaHenk Huismans
Nov 6, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S YuvarajV A Srinivasan
Jul 16, 2013·Virus Research·Laxmi N SarangiBramhadev Pattnaik
Dec 12, 2012·Virology·Paul LawrenceElizabeth Rieder
Jul 7, 2012·Journal of Virological Methods·Yimei CaoZaixin Liu
Oct 7, 2004·Virology·Guangjin LiZhaoxin Zheng
Jul 28, 2007·Veterinary Microbiology·Jia-Long WangZhao-Xin Zheng
Apr 17, 2004·Journal of Immunological Methods·Yong Joo KimMichelle Rémond
Jun 30, 2005·Animal Health Research Reviews·John Pasick
Nov 6, 2010·Hybridoma·Lina MaJie Zhang
Sep 6, 2006·The Journal of Veterinary Medical Science·Ivan-Chen ChengMing-Hwa Jong
Aug 3, 2014·Virology Journal·Ming YangZhidong Zhang
May 12, 2009·Journal of Biosciences·S B NagendrakumarV A Srinivasan
Oct 15, 2013·Transboundary and Emerging Diseases·A NamatovuK Tjørnehøj
Feb 14, 2003·Journal of Virology·Qizu ZhaoPeter W Mason
Nov 11, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jitendra K BiswalRaj Kumar Singh
May 1, 2021·International Journal of Molecular Sciences·Sukyo JeongSang Jick Kim
Sep 6, 2011·Virology Journal·Li-na MaYong-sheng Liu