Antigenic specificity of rheumatoid synovial fluid lymphocytes.

Arthritis and Rheumatism
R M PopeB V Desai

Abstract

The majority of rheumatoid arthritis (RA) synovial fluid lymphocytes (SFL) demonstrate markers that are suggestive of prior activation. While the mechanism(s) responsible is unknown, prior studies have suggested that certain Mycobacterium tuberculosis (MT) antigens may preferentially activate SFL in vitro. We therefore examined the ability of RA SFL to respond to purified protein derivative and an acetone-precipitable MT antigenic complex (AP-MT) and compared this with the responses by peripheral blood lymphocytes (PBL). The responses were contrasted with those elicited with tetanus toxoid (TT) and mitogenic anti-CD3. In patients with RA, the SF proliferative responses to both TT and anti-CD3 were reduced compared with responses by PB. In contrast, the SF response to purified protein derivative was maintained, and that to AP-MT was significantly increased, compared with PB. SF responses to AP-MT antigens were significantly greater than those to TT. The AP-MT activation of T lymphocytes from RA SF was characterized by an earlier peak proliferative response than that noted with matched PB. AP-MT responsiveness was not restricted to HLA-DR4 positive patients. These observations suggest that an epitope(s) contained within the MT co...Continue Reading

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Citations

Oct 1, 1990·Arthritis and Rheumatism·J S GastonP A Bacon
Feb 1, 1993·Arthritis and Rheumatism·H KohsakaD A Carson
May 1, 1992·Immunology Today·M HowellM Cawley
Jun 1, 1992·Baillière's Clinical Rheumatology·J S Gaston
Aug 1, 1994·European Journal of Clinical Investigation·J E TaylorJ A Goodacre
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Jun 1, 1991·Immunological Reviews·J Winfield, W Jarjour
Mar 12, 2005·The Journal of Clinical Investigation·Guangwu XuJingwu Z Zhang
Aug 3, 2005·Cancer Cell International·Richmond T Prehn
Feb 7, 2006·Theoretical Biology & Medical Modelling·Richmond T Prehn
Jan 1, 1991·Springer Seminars in Immunopathology·P ResR de Vries
Feb 1, 1992·Journal of Autoimmunity·R Ramos-RuizJ P López-Bote
Apr 1, 1992·Clinical Immunology and Immunopathology·Y LuR M Pope
Nov 1, 1991·Arthritis and Rheumatism·M Ziff
Jun 1, 1993·Seminars in Arthritis and Rheumatism·D R Schultz, P I Arnold

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