PMID: 2461135Jan 1, 1988Paper

Antigenic variability of Borrelia burgdorferi

Annals of the New York Academy of Sciences
B WilskeM Kramer

Abstract

Borrelia burgdorferi strains (six isolates from North America and 28 isolates from Europe) were analyzed by physicochemical and immunological methods. By SDS-PAGE, all Borrelia burgdorferi strains tested had two major proteins with constant molecular weights of 60 and 41 kDa and one, two, or three variable low molecular weight proteins (OspA = 30-32 kDa, OspB = 34-36 kDa, pC = 21-22 kDa). All combinations--except OspB alone or OspB/pC--were observed. Borrelia burgdorferi strains were different from relapsing fever borreliae by strong reactivity with OspA- and/or pC-specific polyclonal antibodies, whereas relapsing fever borreliae were only weakly reactive. Among 25 Borrelia burgdorferi isolates, seven different serotypes of Borrelia burgdorferi were defined according to their reactivity in the Western blot with three monoclonal OspA-specific antibodies (H5332, H3TS, and LA5), four OspA- or OspB-specific polyclonal antibodies, and 12 polyclonal antibodies against whole borreliae. Antigenic differences between European CSF and skin isolates were observed, all skin isolates (n = 11) belonging to serotype 2 in contrast to only two out of seven CSF isolates. CSF isolates were antigenically heterogenous (serotypes 1, 2, 3, 4, and 5)....Continue Reading

References

Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·A G Barbour, M E Schrumpf
Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·B WilskeK V Busch
May 1, 1986·Infection and Immunity·A G BarbourS L Tessier
Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·V Preac-MursicG Schierz
Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·W Burgdorfer, K L Gage
Jul 1, 1984·Infection and Immunity·A G BarbourS F Hayes
Jun 18, 1982·Science·W BurgdorferJ P Davis
Nov 1, 1982·The Journal of Experimental Medicine·H G StoennerC Larsen

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Citations

Aug 1, 1994·Arthritis and Rheumatism·K Kowal, A Weinstein
Mar 1, 1991·World Journal of Microbiology & Biotechnology·B WilskeE Soutschek
Apr 17, 1990·Klinische Wochenschrift·W MayerW Doering
Apr 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M V AssousG Baranton
Sep 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Karlsson
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·G ZimmerM M Simon
May 1, 1989·Trends in Neurosciences·A R Pachner
Dec 1, 1991·International Journal of Food Microbiology·G M Farrell, E H Marth
Apr 1, 1993·Parasitology Today·E FikrigR A Flavell
Jul 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L GrubhofferP Volf
May 1, 1996·FEMS Microbiology Letters·C Grewe, J H Nuske
Jul 1, 1992·Research in Microbiology·B WilskeR Wallich
May 1, 1993·Research in Microbiology·E Filipuzzi-JennyJ Meyer
Jan 1, 1994·Przegla̧d epidemiologiczny·Z Dziubek
Aug 28, 2001·Biochimie·H HossainG Lochnit
Jun 1, 1997·Research in Microbiology·L R BrunetS R Telford
Jun 1, 1993·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·M Moskophidis, B Luther
Nov 16, 1995·The New England Journal of Medicine·J BerglundR Norrby
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·U E SchaibleM M Simon
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H OliverR S Lane
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E DykhuizenB J Luft
Sep 1, 1992·The Journal of Experimental Medicine·A SădzieneA G Barbour
Aug 1, 1993·The Journal of Experimental Medicine·S R TelfordR A Flavell
Jan 1, 1995·The Journal of Experimental Medicine·E FikrigR A Flavell
Feb 28, 2002·The Journal of Infectious Diseases·Benjamin J LuftCatherine L Lawson
Mar 17, 2004·Vector Borne and Zoonotic Diseases·Eva JanouskovcováMilos Dendis
Jan 1, 1993·Microbiology and Immunology·H KawabataY Yanagihara
Jan 1, 1994·Microbiology and Immunology·H KawabataY Yanagihara
Apr 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P Webster, F Frandsen
Jun 23, 2006·Infection and Immunity·Andrew J NowalkJames A Carroll

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