Antigenic variation as an exploitable weakness of babesial parasites

Veterinary Parasitology
D R Allred, Basima Al-Khedery

Abstract

Babesia bovis and its bovine host interact in many ways, resulting in a range of disease and infection phenotypes. Host responses to the parasite elicit or select for a variety of responses on the part of the parasite, the full range of which is not yet known. One well-established phenomenon, thought to aid parasite survival by evasion of host adaptive immune responses, is the sequential expansion of antigenically variant populations during an infection, a phenomenon referred to as "antigenic variation". Antigenic variation in B. bovis, like that in the human malarial parasite, Plasmodium falciparum, is intimately linked to a second survival mechanism, cytoadhesion. In cytoadhesion, mature parasite-containing erythrocytes bind to the capillary and post-capillary venous endothelium through parasite-derived ligands. The reliance of these parasites on both functions, and on their linkage, may provide opportunities to develop anti-babesial and, perhaps, anti-malarial protection strategies. The development of inhibitors of DNA metabolism in B. bovis may be used to abrogate the process of antigenic variation, whereas small molecular mimics may provide the means to vaccinate against a wide range of variants or to prevent the surface e...Continue Reading

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Citations

Jul 30, 2014·Parasitology·Monica Florin-ChristensenLeonhard Schnittger
Jan 24, 2012·Trends in Parasitology·Vesna MatijatkoTheo P Schetters
Oct 24, 2006·Veterinary Parasitology·Th P M SchettersA N Vermeulen
Jul 24, 2012·Veterinary Parasitology·Tserendorj MunkhjargalIkuo Igarashi
Nov 28, 2012·International Journal for Parasitology·Yingling HuangDavid R Allred
Jun 21, 2011·Veterinary Parasitology·Carlos E Suarez, Susan Noh
Jan 29, 2019·International Journal for Parasitology·Carlos E SuarezBrian M Cooke

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