PMID: 7031128Dec 1, 1981Paper

Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses

The Journal of Hygiene
M HamzawiC W Potter

Abstract

Inactivated vaccines prepared form influenza virus strains obtained by the recombination of A/PR/8/34 (H1N1) or A/FM/1/47 (H1N1) viruses with A/Victoria/3/75 (H3N2) virus, were tested for their antigenicity in hamsters. The parental origin of the genes of each cloned recombinant virus was determined by polyacrylamide gel electrophoresis, and vaccines prepared from each strain by concentration, purification on sucrose density gradients and inactivation with formalin. All the recombinant strains used in these studies possessed surface haemagglutinin and neuraminidase antigens derived from the A/Victoria/75 parent strain. On inoculation into hamsters, at equivalent concentrations, these vaccines varied in their ability to induce haemagglutination-inhibiting (HI) antibodies in the serum. This variation was not dependent on concentration and was observed using neutralization and single radial haemolysis, as well as HI. The possible reasons for the findings are discussed.

References

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E D Kilbourne
Feb 1, 1979·Postgraduate Medical Journal·F M Davenport
Jan 1, 1977·Virology·M B RitcheyJ L Schulman
Jan 1, 1977·Journal of Biological Standardization·R J FentonC W Potter
Dec 1, 1976·Medical Microbiology and Immunology·R JenningsC W Potter
Jan 1, 1972·Advances in Immunology·E R Unanue
Aug 2, 1972·Nature: New Biology·C M Brand, J J Skehel
Jan 1, 1972·Medical Microbiology and Immunology·H Bachmayer, G Schmidt
Feb 1, 1973·Virology·N G WrigleyC M Brand
Jan 1, 1973·Archiv für die gesamte Virusforschung·R Jennings, C W Potter
Apr 1, 1972·The Journal of General Virology·D McCahon, G C Schild
Mar 1, 1980·The Journal of Infectious Diseases·M BaezE D Kilbourne
Jan 1, 1980·Archives of Virology·H Abou-DoniaC W Potter
Mar 1, 1958·The Journal of Hygiene·S FAZEKAS DE ST GROTH, D O WHITE
Sep 1, 1958·The Journal of Hygiene·S F DE ST GROTHK J LAFFERTY
Feb 1, 1965·Analytical Biochemistry·C B LAURELL

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