PMID: 9359Jun 1, 1976

Antigenicity of type-specific pneumococcal polysaccharides in rats

Infection and Immunity
J D Coonrod, B Rylko-Bauer

Abstract

Hemagglutinating antibody responses of Lewis-Wistar and Sprague-Dawley rats to graded doses of type-specific pneumococcal polysaccharide were measured. Rats given a small dose (0.2 to 50 mug)of type 1 or 8 polysaccharide intraperitoneally developed type-specific hemagglutinating antibody. Rats given larger doses of polysaccharide (greater than or equal to200 mug) did not develop detectable hemagglutinating antibody, and they were unresponsive to a subsequence injection of a small (and normally antigenic) dose of polysaccharide. There was prolonged antigenemia in rats injected with a large dose of polysaccharide. There was prolonged antigenemia in rats injected with a large dose of polysaccharide, and the kinetics of antigen clearance in these animals resembled that reported for mice with polysaccharide immunological paralysis. These results indicate that a phenomenon resembling immunological paralysis with type-specific pneumococcal polysaccharides can be produced in rats.

Related Concepts

Antibodies, Bacterial
Dose-Response Relationship, Drug
Isohemagglutinins
Natural Immunosuppression
Polysaccharides, Bacterial
Streptococcus pneumoniae

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