Antigenotoxic effects of piquiá (Caryocar villosum) in multiple rat organs.

Plant Foods for Human Nutrition
Mara Ribeiro AlmeidaMaria Lourdes Pires Bianchi

Abstract

This study investigated the in vivo genotoxicity of piquiá pulp (Caryocar villosum) and its potential antigenotoxicity on doxorubicin (DXR)-induced DNA damage by comet assay and micronucleus test. In addition, the phytochemicals present in piquiá pulp were determined. Piquiá fruit pulp (75, 150 or 300 mg/kg b.w.) was administered by gavage to Wistar rats for 14 days, and the animals received an injection of saline or DXR (15 mg/kg b.w., i.p.) 24 h before they were euthanized. The phytochemical analysis revealed the presence of carotenoids; phenolic compounds, including flavonoids; tannins and α-tocopherol in piquiá pulp. No statistically significant differences were observed in the evaluated parameters, demonstrating the absence of cytotoxic and genotoxic effects of piquiá pulp at all tested doses. In liver, kidney, cardiac and bone marrow cells, piquiá significantly reduced the DNA damage induced by DXR. Our results showed that the lowest piquiá dose caused the largest decrease in DNA damage and the highest dose caused the smallest decrease, demonstrating an inverse dose-response of piquiá pulp. Furthermore, we observed a difference in the potential antigenotoxic effects in several tissues. In conclusion, our results demonstra...Continue Reading

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Citations

Aug 7, 2012·Plant Foods for Human Nutrition·Janet MorffiJ Javier Espinosa-Aguirre
Mar 1, 2013·Journal of Medicinal Food·Mara Ribeiro AlmeidaMaria Lourdes Pires Bianchi
Jun 21, 2016·Journal of Ethnopharmacology·Patrícia Rosane Leite de FigueiredoIrwin Rose de Alencar Menezes
Dec 6, 2016·Nutrients·Amaya Azqueta, Andrew Collins
Aug 24, 2017·Brazilian Journal of Biology = Revista Brasleira De Biologia·I M S SalesA P Peron
May 11, 2019·Journal of Medicinal Food·Nara Rúbia Rodrigues do Nascimento-Silva, Maria Margareth Veloso Naves

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