Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
María-Dolores Lozano-BaenaAngeles Alonso-Moraga

Abstract

Cruciferous vegetables are well known and worldwide consumed due to their health benefits and cancer prevention properties. As a desirable cruciferous plant, Ethiopian mustard (Brassica carinata A. Braun) and its glucosinolate sinigrin were tested in the in vivo Drosophila melanogaster (SMART) and the in vitro HL60 (human promyelocytic leukaemia cell line) systems. High performance liquid chromatography (HPLC) analysis of plant samples confirmed the presence of sinigrin as principal B. carinata glucosinolate. SMART was performed by feeding D. melanogaster larvae either with different concentrations of plant/compound samples or combining them with hydrogen peroxide (a potent oxidative mutagen) being both antimutagenics. HL60 assays showed the tumoricidal activity of plant samples (IC50 = 0.28 mg·mL(-1)) and the breakdown products of sinigrin hydrolysis (IC50 = 2.71 µM). Our results enhance the potential of B. carinata as health promoter and chemopreventive in both systems and the leading role of sinigrin in these effects.

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Citations

Jan 23, 2016·Nutrients·María-Dolores Lozano-BaenaAntonio de Haro-Bailón
Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anisha MazumderJeanetta du Plessis
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahmudur RahmanBronwyn J Barkla
Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvia MainaHo-Youn Kim

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