PMID: 7547708May 1, 1995Paper

Antigens released at schizont burst stimulate Plasmodium falciparum-specific CD4+ T cells from non-exposed donors: potential for cross-reactive memory T cells to cause disease

International Immunology
J CurrierM F Good

Abstract

In an individual experiencing the first attack of malaria, symptoms of disease can occur at very low parasitemia. T cells and cytokines have been implicated in the etiology of disease symptoms, and others and ourselves have shown that T cells from non-exposed individuals can be stimulated by malaria parasites. Here, we show that nine from 11 blood samples, naturally infected with malaria parasites, could stimulate proliferation of a malaria-specific T cell clone derived from a non-exposed donor. T cells were able to respond to infected blood at a parasitaemia as low as 0.000003% (comparable to the level at which individuals can first experience symptoms of malaria) and secrete cytokines implicated in pathology. Antigens capable of stimulating T cells are expressed throughout the blood stage, but are specifically released at the time of schizont rupture. While most TCR V beta genes are expressed during the T cell response of naive donors to malaria parasites, processing of parasite antigens is blocked by chloroquine and monensin, and activation of 36 of 41 malaria-specific clones tested was restricted by defined MHC class II allelic antigens, strongly suggesting that parasites do not act as mitogens nor as superantigens. The clo...Continue Reading

Citations

Jun 20, 2000·Parasitology Today·E M Riley
Jan 25, 2003·Parasitology International·Hisami WatanabeToru Abo
Dec 12, 2001·Clinical and Experimental Immunology·M S RheeE M Riley
Mar 20, 2001·Infection and Immunity·M Hensmann, D Kwiatkowski
May 23, 1998·Annual Review of Immunology·M F GoodL H Miller
Feb 14, 2014·The Journal of Infectious Diseases·Danielle I StanisicLouis Schofield
Aug 27, 2014·Mediators of Inflammation·Sin Yee GunLaurent Rénia
Sep 14, 2004·Immunological Reviews·Siske S Struik, Eleanor M Riley
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis M NdunguJean Langhorne
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas JacobsBernhard Fleischer
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kaiissar MannoorToru Abo

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