Antigenuria in chronic chagasic patients detected by a monoclonal antibody raised against Trypanosoma cruzi.

Transactions of the Royal Society of Tropical Medicine and Hygiene
A M KatzinW Colli

Abstract

A monoclonal antibody (B2/5) raised against Trypanosoma cruzi was able to immunoprecipitate a major 100 kDa polypeptide in 84% of the urines collected from chronic chagasic patients. Other polypeptides were also detected. The antibody recognized polypeptides on the surface of epimastigotes (150-25 kDa) and metacyclic trypomastigotes (150-50 kDa), suggesting that the antigens share a common epitope.

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Citations

Jan 24, 2014·PLoS Neglected Tropical Diseases·Rana NagarkattiAlain Debrabant
Jan 1, 1991·Experimental Parasitology·M F GonçalvesW Colli
Oct 3, 2014·PLoS Neglected Tropical Diseases·Yagahira E Castro-SesquenUNKNOWN Working Group on Chagas Disease in Bolivia and Peru
Feb 27, 2016·PLoS Neglected Tropical Diseases·Yagahira E Castro-SesquenUNKNOWN Chagas/HIV Working Group in Bolivia and Peru
Mar 2, 2016·The American Journal of Tropical Medicine and Hygiene·Verónica YauriRobert H Gilman

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